Chagas Disease - ✔✔Caused by Trypanosoma cruzi parasite passed in the feces of Reduviidae/kissing bug
Penetrates broken skin or intact mucous membranes forming a pseudocyst releasing inflammatory infiltrates into myoc
...
Chagas Disease - ✔✔Caused by Trypanosoma cruzi parasite passed in the feces of Reduviidae/kissing bug
Penetrates broken skin or intact mucous membranes forming a pseudocyst releasing inflammatory infiltrates into myocytes; stains with Giemsa & Wright
Romana sign occurs when portal of entry is the conjunctiva or eyelid
May resulting in:
Enlarged heart- CHF, sudden cardiac arrest
Enlarged esophagus- difficulty swallowing
Enlarged colon- abdominal pain or constipation
Treat with benznidazole or nifurtimox
Monocytes - ✔✔cell with half-moon shaped nucleus that participates in phagocytosis
Chronic graft rejection - ✔✔multifactorial but typically involves arteriosclerosis
HLA-B27 - ✔✔PAIR:
Psoriasis
Ankylosing spondylitis- chronic synovitis destroying cartilage typically in young men
Inflammatory bowel dz- Crohn's & UC
Reactive Arthritis-
Reactive Arthritis - ✔✔Arthritis as a reaction to a bacterial infection such as Campylobacter, Chlamydia, Salmonella, Shigella, or Ureaplasma.
Associated with conjunctivitis & uveitis
Gaucher (Type 1) - ✔✔AR Lysosomal storage disease
Accumulation of sphingolipid glucocerebroside
Most common
Wrinkled tissue paper
I Cell disease - ✔✔Failure of Golgi apparatus to phosphorylate mannose 6-phosphate the marker to export enzymes to lysosomes resulting in accumulation of lysosomal enzymes in serum
Nitroblue tetrazolium test - ✔✔Aqualitative test to determine defects in NADPH oxidase
Negative: CGD
Positive: Acute Hepatitis, Mono
CGD (chronic granulomatous disease) - ✔✔inability to produce NADPH oxidase; susceptible to Cat + organisms; elevated neutrophils w/ normal T cell
Gp91 phox subunit: heme binding subunit of superoxide generating NADPH
Treat with interferon gamma
Clarithromycin (macrolide) -
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