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Acute Promylocytic Leukemia (APL)/ ASCP MB Exam (Complete Solution) Graded A+

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Acute Promylocytic Leukemia (APL)/ ASCP MB Exam (Complete Solution) Graded A+ Acute Promylocity Leukemia (APL) ✔✔ t(15:17) PML / RARa genes Chronic Myelogenous Leukemia (CML) ✔✔ t(9:2 ... 2) a.k.a. Philadelphia chromosome ABL1 / BCR genes Burkitt's non-Hodkin's Lymphoma ✔✔ t(8:14) dysregulation of c-myc gene breakpoints on ch.8 spread over 190kbp region 5' to 3' Follicular non-Hodkin's Lymphoma ✔✔ t(14:18) IgH / BCL2 genes Mantle Cell Lymphoma (MCL) ✔✔ t(11:14) CCND1 / IgH genes overexpression of cyclin D1 (cell cycle gene) MALT Lymphoma (a.k.a. Marginal Zone) ✔✔ t(11:18) API2 / MLT genes "mucosa-associated lymphoid tissue" Haploid Genome ✔✔ 3.3 billion bp Carbamazepine Resistance ✔✔ HLA B1502 Factor V Leiden ✔✔ c.1691G>A / p.R506Q causes Thrombophilia Cystic Fibrosis mutation ✔✔ delta F508, 3bp deletion HERceptin Therapy ✔✔ HER2+/neu Overexpression of HER2 receptors causing cancer cells to grow Vancomycin Resistance (Enterococcus) ✔✔ van A MRSA (resistant staph) ✔✔ mec A Mycobacterium tuberculosis ✔✔ katG, inhA [Show More]

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