Central Dogma of Genetic Medicine Assignment 2020

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Central Dogma of Genetics Assignment OVERVIEW This worksheet complements the Central Dogma and Genetic Medicine Click & Learn from HHMI BioInteractive. This worksheet comes directly from HHMI BioI... nteractive. PROCEDURE As you proceed through the Click & Learn, follow the instructions below and answer the questions in the spaces provided. 1. Let’s review! The central dogma of molecular biology refers to the process of gene expression. Write the definition of gene expression in your own words. . 2. Click on the “Central Dogma” menu tab at the top of the screen. The table below outlines the steps in eukaryotic gene expression. Click on each tab in the tutorial and briefly summarize each step below. There are little arrows next to each molecule involved. Click on these to get more information on each molecule. Gene expression steps Molecules involved What molecules and proteins are involved in this step? Summary What happens during this step? Transcription RNA Splicing mRNA Transport Translation Protein Processing . 3. Mutations in the DNA can affect the structure and function of proteins. Some mutations may even cause genetic diseases. Scientists and doctors can intervene at different points during gene expression to develop treatments for such genetic diseases – or genetic medicine. Let’s learn about the genetic medicines that are being developed. Select the “Genetic Medicine” tab located on the top right of the screen in the tutorial. Click on the tab corresponding to the genetic medicine that your instructor assigns to you, or scroll through the interactive and click on the pink “+” sign labeled with that genetic medicine. Read the “Genetic Medicine” tab material, watch the video, and read the information in the “Learn more” link. Then complete the appropriate row below. Genetic Medicine CRISPR- Cas9 Gene Therapy Gene Switches Exon Skipping RNA Interference Small Molecule Drug 4. Now let’s learn about some of the diseases that may be treated using these genetic medicines. Scroll through the interactive tutorial and click on the pink “+” sign that is labeled with the disease that your instructor has assigned to you. Next, click on the “Case Study” tab at the top to reveal information about the disease. Read the “Case Study” material, watch the video, and read the information in the “Learn more” link. Then fill in the appropriate row in the table below. Name of Disease What are the key characteristics of the disease and whom does it affect? How can the featured genetic medicine be used to treat the disease? Leber Congenital Amaurosis Sickle Cell Disease Duchenne Muscular Dystrophy Huntington’s Disease Cystic Fibrosis [Show More]

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