The optimum use of chemotherapy drugs in combination is based on which premise(s)? Select
all that apply.
a. Drugs should have different mechanisms of action.
b. Each medication should be effective by itself.
c. Toxi
...
The optimum use of chemotherapy drugs in combination is based on which premise(s)? Select
all that apply.
a. Drugs should have different mechanisms of action.
b. Each medication should be effective by itself.
c. Toxicity should concentrate in one body tissue.
d. Overlappping toxicity among the agents should be minimal.
e. Each drug should have the same mechanism of action.
Rationale: Different mechanisms of action is the greatest benefit of combination drug therapy in
cancer because different chemo drugs affect the cancer cell in different time of the cycle and in a
different way so, its decrease the resistance of cancer cell which decreases the chance of survival of
cancer cells. Minimal toxicity is the main focus during the use of combined chemotherapy because of
its increases the chance of drug interaction, which becomes toxic for the body.
Reference: Frei E III, Eder JP. Combination Chemotherapy. In: Kufe DW, Pollock RE, Weichselbaum
RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Available
from: https://www.ncbi.nlm.nih.gov/books/NBK13955/
Question 2: Multiple Answer- 10 points
A client develops neutropenia after receiving chemotherapy. Which information about ways to
prevent infection will the nurse include in the teaching plan? Select all that apply.
a. Cook food thoroughly before eating.
b. Choose low fiber, low residue foods.
c. Avoid public transportation such as buses.
d. Use rectal suppositories if needed for constipation.
e. Talk to the oncologist before having any dental work.
Rationale: Chemotherapy-induced neutropenia is a major concern to oncologists. In
neutropenia, there is a decreased level of the neutrophils, making a person weak with poor immunity
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