NURS-6521
100-question Exam which will assess your knowledge on the Learning Resources from Weeks 1-6.
Time limit of 2 hours.
Multiple choice or multiple selection.
Pharmacodynamics: how the drug effects the bo
...
NURS-6521
100-question Exam which will assess your knowledge on the Learning Resources from Weeks 1-6.
Time limit of 2 hours.
Multiple choice or multiple selection.
Pharmacodynamics: how the drug effects the body
Pharmacokinetics: how the body effects the drug
Understand the implications of changing renal function on creatinine & drug dosing.
Kidney/Renal functions :
Filters blood = Remove Waste, Toxins, and Extra Fluid from the body
Returns needed substances to the blood – & the remainder becomes urine
Removes acid produced by cells of the body to maintain balanced water, salts; minerals
Makes hormones that control BP, make RBCs; keeps bones strong
Creatinine: Measures kidney function - byproduct of muscle metabolism (creatinine phosphate)
Normal Serum Creatinine levels: 0.6-1.3 mg/dL - healthy kidney (Easily filters & excretes creatinine)
More Reliable than BUN. Creatinine is Not Absorbed by the kidneys.
Rises indicate renal damage or failure = Kidney is unable to properly filter & excrete waste (creatinine) = Lab
Value rises in the serum.
Creatinine = Kidney Function = Requires a decreased dose of medication or different dosing schedule
= Renal Dosing
What is the impact of the following on drug levels and dosing:
Cirrhosis: a disease in which normal liver cells are replaced by scar tissue.
As liver cells die, the organ makes less of the proteins that regulate fluid retention & blood clotting and
the liver loses its ability to metabolize the pigment bilirubin.
Liver/Hepatic functions :
Produces proteins that help clot blood
Removes / neutralizes poisons, drugs and alcohol
Manufactures bile that helps the body absorb fats & cholesterol
Helps maintain normal blood sugar levels
Regulates hormones
With Cirrhosis - the liver fails to detoxify the blood & it becomes less able to metabolize medications, which
magnifies their effects. Eventually toxins build up in the brain & can produce:
Increased sensitivity to drugs
Levels of medication will be higher d/t decreased metabolism
Requires decreased dose of medication
Liver/Hepatic Function = Ability to metabolize medication = Requires a decreased dose of
medication or different dosing schedule = Hepatic Dosing
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