Psychopharmacology Drugs the Brain and Behavior 3rd Edition Meyer Nursing Test Bank

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Test Bank to accompany Psychopharmacology, Third Edition Meyer • Quenzer Chapter 1: Principles of Pharmacology Multiple Choice 1. _______ refer(s) to specific molecular changes that occur when... a drug binds to a particular target site or receptor, while _______ are the resulting widespread alterations in function. a. Drug action; therapeutic effects b. Side effects; drug effects c. Therapeutic effects; side effects d. Drug action; drug effects Answer: d Textbook Reference: Pharmacology: The Science of Drug Action 2. After drug administration has occurred, the amount of drug in the blood that is free to bind at specific target sites is referred to as a. the therapeutic dose. b. first-pass effects. c. bioavailability. d. ED50. Answer: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 3. The specific molecular changes that occur when a drug binds to a particular target site or receptor are referred to as a. drug effects. b. drug action. c. side effects. d. placebo effects. Answer: b Textbook Reference: Pharmacology: The Science of Drug Action 4. Which of the following is not a possible explanation for placebo effects? a. Pavlovian conditioning b. Genetic variation c. Drug competition d. Expectation of outcome Answer: c Textbook Reference: Pharmacology: The Science of Drug Action 5. The _______ administration of oxytocin has been proposed as a treatment for autism. a. intravenous b. oral c. intranasal d. intracerebral Answer: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 6. Which factor does not affect the pharmacokinetics of a drug? a. Route of administration b. Lipid solubility c. Depot binding d. Drug action Answer: d Textbook Reference: Pharmacokinetic Factors Determining Drug Action 7. First-pass metabolism occurs when drugs are taken a. orally. b. intravenously. c. subcutaneously. d. nasally. Answer: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 8. The area postrema is one area in the brain where the _______ is not complete. a. cerebrospinal fluid b. blood–brain barrier c. choroid plexus d. phospholipid membrane Answer: b Textbook Reference: Pharmacokinetic Factors Determining Drug Action 9. First-pass metabolism occurs with orally administered drugs because a. their absorption is slowed by food. b. drugs absorbed into the bloodstream from the stomach go to the liver on the way to general circulation. c. drugs must first survive the acidic environment of the stomach. d. salivary enzymes in the mouth begin the process of metabolism. Answer: b Textbook Reference: Pharmacokinetic Factors Determining Drug Action 10. Toxic substances in the blood trigger a vomiting response by activating the a. blood–brain barrier. b. choroid plexus. c. area postrema. d. median eminence. Answer: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 11. Drugs administered _______ have the most rapid onset of action. a. subcutaneously b. intramuscularly c. orally d. intravenously Answer: d Textbook Reference: Pharmacokinetic Factors Determining Drug Action 12. Ionization of a drug depends on the _______ of the solution and the _______ of the drug. a. pH; pKa b. pKa; pH c. concentration; lipid solubility d. pH; concentration Answer: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 13. The absorption of a drug depends on all of the following except a. lipid solubility. b. ionization. c. body temperature. d. the concentration of the drug. Answer: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 14. Drugs that are _______ should be avoided by women of childbearing age. a. teratogenic b. able to cross the placental barrier c. psychoactive d. highly lipid-soluble Answer: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 15. Agents that induce developmental abnormalities in a fetus are known as a. psychoactive drugs. b. illicit drugs. c. teratogens. d. placental drugs. Answer: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 16. Depot binding is said to occur when drugs a. bind to their target sites. b. bind to inactive sites. c. compete for binding sites. d. are excreted before binding. Answer: b Textbook Reference: Pharmacokinetic Factors Determining Drug Action 17. Which statement about depot binding is false? a. It reduces the concentration of drug at its site of action. b. It may delay the onset of drug action. c. It may prolong drug action by disrupting normal metabolism. d. It increases the concentration of drug at its site of action by releasing large quantities at once. Answer: d Textbook Reference: Pharmacokinetic Factors Determining Drug Action 18. Drug metabolism mostly occurs in the _______ and usually makes a drug more _______ soluble. a. kidneys; fat b. liver; fat c. liver; water d. kidneys; water Answer: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 19. Which statement about drug clearance by first-order kinetics is false? a. Molecules of a drug are cleared at a constant rate regardless of drug concentration. b. Molecules of a drug are cleared at an exponential rate. c. A constant fraction of the free drug in the blood is removed in each time interval. d. Clearance of most drugs occurs in this manner. Answer: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 20. Ethyl alcohol (ethanol) is an example of a drug that is eliminated a. by first-order kinetics. b. by zero-order kinetics. c. by second-order kinetics. d. at the point that six half-lives have passed. Answer: b Textbook Reference: Pharmacokinetic Factors Determining Drug Action 21. Biotransformation of drugs in the liver often occurs in two stages; phase I changes are _______ and include _______. a. nonsynthetic; conjugation b. synthetic; conjugation c. nonsynthetic; oxidation d. synthetic; oxidation Answer: c Textbook Reference: Pharmacokinetic Factors Determining Drug Action 22. Biotransformation of drugs can result in the formation of _______, which enter the circulation and cause _______. a. inactive metabolites; sensitization b. active metabolites; prolonged drug action c. active metabolites; tolerance d. enzymes; tolerance Answer: b Textbook Reference: Pharmacokinetic Factors Determining Drug Action 23. Which statement about water-soluble metabolites formed in the liver is false? a. They may return to the circulation and act on target tissues. b. They may be filtered out by the kidneys. c. They may be excreted into bile. d. They may be eliminated with the feces. Answer: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 24. Which statement about microsomal enzymes in the liver is false? a. They are highly specific and act only on certain compounds. b. They are located on the smooth endoplasmic reticulum. c. The cytochrome P450 family is one of the most important. d. They can metabolize toxins and environmental pollutants as well as drugs. Answer: a Textbook Reference: Pharmacokinetic Factors Determining Drug Action 25. Repeated use of many psychoactive drugs ca [Show More]

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