NSG 6005 / NSG6005 PHARM MIDTERM EXAM LATEST 2021 GRADED A

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1) A patient’s nutritional intake and lab work reflect hypoalbuminemia. This is critical to prescribing because: Distribution of drugs to target tissue may be affected. 2) Drugs that have a signif... icant first-pass effect: Are rapidly metabolized by the liver and may have little if any desired action. 3) The route of excretion of a volatile drug will likely be: The lungs 4) The point in time on the drug concentration curve that indicates the first sign of a therapeutic effect is the: Onset of action 5) Factors that affect gastric drug absorption include: Lipid solubility of the drug 6) Which one of the following statements about bioavailability is true? Bioavailability issues are especially important for drugs with narrow therapeutic ranges or sustained release mechanisms. 7) Steady state is: When the amount of drug in the body remains constant. 8) The time required for the amount of drug in the body to decrease by 50% is called: Halflife 9) An advantage of prescribing a sublingual medication is that the medication is: Absorbed rapidly 10) Drugs that use CYP3A4 isoenzymes for metabolism may: Both A and B(Induce the metabolism of another drug; inhibit the metabolism of another drug) 11) A nurse practitioner would prescribe the liquid form of ibuprofen for a six-year-old because: A six-year-old may have problems swallowing a pill 12) The first step in the prescribing process according to the World Health Organization is: Diagnosing the patient’s problem 13) Patient education regarding prescribed medication includes: Discussion of expected ADRs 14) Pharmacokinetic factors that affect prescribing include: Bioavailability 15) Infants and young children are at higher risk of ADRs due to: Lack of safety and efficacy studies in the pediatric population. 16) Infants and young children are at higher risk of ADRs due to: Lack of safety and efficacy studies in the pediatric population. 17) The elderly are at high risk of ADRs due to: Age-related decrease in renal-function 18) The type of ADR that is the result of an unwanted but otherwise normal pharmacological action of a drug given in the usual therapeutic doses is: Type A 19) A patient may develop neutropenia from using topical Silvadene for burns. Neutropenia is: A cytoxic hypersensitivity reaction 20) The angiotensin converting enzyme (ACE) inhibitor Lisinopril is a known teratogen. Teratogens cause Type __ ADR. D 21) A twenty-four-year-old male received multiple fractures in a motor vehicle accident that required significant amounts of opioid medication to treat his pain. He is at risk for Type __ ADR when he no longer requires the opioids. E 22) Which of the following factors may adversely affect a patient’s adherence to a therapeutic drug regimen? Both A and B 23) Nonadherence is especially common in drugs that treat asymptomatic conditions, such as hypertension. One way to reduce the likelihood of nonadherence to these drugs is to prescribe a drug that: Has a tolerability profile with less of the adverse effects that are considered “irritating,” such as nausea and dizziness This study source was downloaded by 100000831988016 from CourseHero.com on 03-18-2022 03:52:28 GMT -05:00 https://www.coursehero.com/file/28726324/Midtermdocx/ 24) Patients with psychiatric illnesses have adherence rates to their drug regimen between 35% and 60%. To improve adherence in this population, prescribe drugs: With a longer half-life so that missed doses produce a longer taper on the drug curve 25) Genetic polymorphisms account for differences in metabolism, including: All of the above (Poor metabolizers (PMs) that lack a working enzyme; Intermediate metabolizers (IMs) that have on working, wild-type allele and one mutant allele; Extensive metabolizers (EMs), with two normally functioning alleles) 26) Warfarin resistance may be seen in patients with VCORC1 mutation, leading to: Decreased response to warfarin 27) Genetic testing for VCORC1 mutation to assess potential warfarin resistance is required prior to prescribing warfarin. False 28) Carbamazepine has a black box warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy due to: Increased risk for Stevens-Johnson syndrome in Asian patients with HLAB*1502 allele 29) Herbs and supplements are tested for safety by the FDA. False 30) Carbamazepine has a black box warning recommending testing for the HLA-B*1502 allele in patients with Asian ancestry prior to starting therapy due to: Increased risk for Stevens-Johnson syndrome in Asian patients with HLAB*1502 allele 31) Common OTC pain relievers such as acetaminophen or ibuprofen: Educate patients and guide them to appropriate sources of care. 32) Common OTC pain relievers such as acetaminophen or ibuprofen: Are harmful if taken in higher-than-recommended amounts 33) When obtaining a drug history from Harold, he gives you a complete list of his prescription medications. He denies taking any other drugs, but you find that he occasionally takes aspirin for his arthritis flare-ups. This is an example of: A common misconception that intermittently taken OTC medications are not an important part of his drug history 34) Patients with pheochromocytoma should avoid which of the following classes of drugs due to the possibility of developing hypertensive crisis? Beta 2 agonist 35) Harold, a forty-two-year-old African American, has moderate persistent asthma. Which of the following asthma medications should he use cautiously, if at all? Salmeterol, an inhaled long-acting beta-agonist 36) Long-acting beta-agonists received a black box warning from the US Food and Drug Administration due to the: Increased risk of asthma-related deaths when long-acting beta-agonists are used [Show More]

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