MSN 571 Quiz 2 Study Guide. Complete.Antibiotics
Review terminology:
1. Selective Toxicity: The ability of a drug to injure a target cell or target organism without
injuring other cells or organisms that are in intima
...
MSN 571 Quiz 2 Study Guide. Complete.Antibiotics
Review terminology:
1. Selective Toxicity: The ability of a drug to injure a target cell or target organism without
injuring other cells or organisms that are in intimate contact with the target. Refers to the
ability of an antibiotic to injure only invading microbes and avoiding injuring the host.
2. Culture and Sensitivity test: Is a test done when trying to treat for infection. Culture is
to determine the bacteria or fungus causing the infection . Sensitivity checks for what
kind of medicine will work best against the bacteria or fungus. Test used to test drug
sensitivity is the disk diffusion test, also known as the kirby-bauer test.
3. Mechanisms of Resistance : decreases concentration of a drug at its site of action; alters
the structure of a drug target molecules; produces a drug antagonist; causes drug
inactivation. Broad spectrum antibiotics promote the emergence of drug resistance.
4. CYP3A4: inhibitor is Drugs used for erectile dysfunction ; it suppresses the metabolism
of sildenafil (viagra), thereby increasing its level. Combination should be used with
caution.
● Intraconazole (antifungal) inhibits CYP3A4
5. CYP450: Cytochrome P450 Enzyme 17 inhibitor
Abiraterone ( Zytiga) indicated for combined use with prednisone to treat metastatic
castration-resistant prostate cancer, if castration has not occured it can inhibit androgen
production by the testes.
Ketoconazole ( Nizoral) used for fungal infections, can be used off label for prostate
● Azoles( antifungal ) has the ability to inhibit CYP450
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