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Comprehensive Basic Science Exam (CBSE) Review Set I (with COMPLETE SOLUTION) Study Guide

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Chagas Disease - ✔✔Caused by Trypanosoma cruzi parasite passed in the feces of Reduviidae/kissing bug Penetrates broken skin or intact mucous membranes forming a pseudocyst releasing inflammato ... ry infiltrates into myocytes; stains with Giemsa & Wright Romana sign occurs when portal of entry is the conjunctiva or eyelid May resulting in: Enlarged heart- CHF, sudden cardiac arrest Enlarged esophagus- difficulty swallowing Enlarged colon- abdominal pain or constipation Treat with benznidazole or nifurtimox Monocytes - ✔✔cell with half-moon shaped nucleus that participates in phagocytosis Chronic graft rejection - ✔✔multifactorial but typically involves arteriosclerosis HLA-B27 - ✔✔PAIR: Psoriasis Ankylosing spondylitis- chronic synovitis destroying cartilage typically in young men Inflammatory bowel dz- Crohn's & UC Reactive Arthritis- Reactive Arthritis - ✔✔Arthritis as a reaction to a bacterial infection such as Campylobacter, Chlamydia, Salmonella, Shigella, or Ureaplasma. Associated with conjunctivitis & uveitis Gaucher (Type 1) - ✔✔AR Lysosomal storage disease Accumulation of sphingolipid glucocerebroside Most common Wrinkled tissue paper I Cell disease - ✔✔Failure of Golgi apparatus to phosphorylate mannose 6-phosphate the marker to export enzymes to lysosomes resulting in accumulation of lysosomal enzymes in serum Nitroblue tetrazolium test - ✔✔Aqualitative test to determine defects in NADPH oxidase Negative: CGD Positive: Acute Hepatitis, Mono CGD (chronic granulomatous disease) - ✔✔inability to produce NADPH oxidase; susceptible to Cat + organisms; elevated neutrophils w/ normal T cell Gp91 phox subunit: heme binding subunit of superoxide generating NADPH Treat with interferon gamma Clarithromycin (macrolide) - [Show More]

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