BIOS390 Molecular Biology
Week 7 Study Guide Name: ERIC KYLE
Question Set 1
(TCO 10) What are minisatellites and microsatellites?
(TCO 10) Repeat length for minisatellite is
(TCO 10) Repeat length for
...
BIOS390 Molecular Biology
Week 7 Study Guide Name: ERIC KYLE
Question Set 1
(TCO 10) What are minisatellites and microsatellites?
(TCO 10) Repeat length for minisatellite is
(TCO 10) Repeat length for a microsatellite is
Question Set 2
(TCO 10) Forensic DNA typing often involves recovery of very tiny amounts of DNA from a crime scene. What is a major concern in analyzing this DNA?
(TCO 10) Find the incorrect statement.
1. Different individuals differ in the length of the repeat sequences.
2. For a boy child, the bands obtained during DNA typing, 50% come from dad and the remaining 50% is random.
3. Single locus probes during minisatellite analysis are more useful.
4. with the help of PCR, even a single cell is enough for DNA typing.
(TCO 10) Find the incorrect statement.
1. STR analysis is used more than minisatellite analysis.
2. The first step in STR analysis is digestion of DNA.
3. mtDNA can be used to determine maternal lineage.
4. Nuclear DNA is less stable than mtDNA.
Question Set 3
(TCO 11) Which statement is not true about cancer?
1. Cancer results from the accumulation of many genetic changes.
2. Gene mutations that increase the risk for developing cancer are always inherited.
3. Cancer cells grow in an uncontrolled and invasive way.
4. Cancer cells are immortal.
(TCO 11) The process by which cancer cells travel from the tissue of origin to other parts of the body is
(TCO 11) Can surgery successfully cure a patient of a cancer that has metastasized?
1. No; all the body cells of the patient are dividing uncontrollably.
2. Yes; surgery could remove all the patient’s cells with defective cell-cycle regulation.
3. No; cancer cells are no longer localized in one spot in the patient.
4. Yes; if the patient’s tumor is benign.
Question Set 4
(TCO 11) Cancer is a multi-step disease that requires
1. at least 4–8 genetic changes over the course of years.
2. mutation of the cancer gene.
3. at least 20 genetic changes over the course of years.
4. at least 4–8 genetic changes over the course of days.
(TCO 11) Chemical agents that cause cancer are known as
1. transformers.
2. carcinogens.
3. tumor suppressors.
4. oncogenes.
(TCO 11) Normal cells undergo _____ and become cancerous.
1. Conjugation
2. Pasteurization
3. Transformation
4. Suppression
Question Set 5
(TCO 11) What is a tumor suppressor gene?
(TCO 11) What is an oncogene?
(TCO 11) Tumor viruses can cause cancer by
1. encoding an oncogene.
2. activating proto-oncogenes.
3. activating retinoblastoma protein.
4. 1 and 2
Question Set 6
(TCO 10) List two differences between minisatellites to microsatellites. Why is analysis in microsatellites more widely used?
Question Set 7
(TCO 10) Compare DNA microarrays to protein microarrays. List similarities and differences.
Question Set 8
(TCO 11) Distinguish between “oncogenes,” “proto-oncogenes,” and “tumor suppressor genes.”
Oncogenes
Proto-oncogenes
Tumor Suppressor genes
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