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DAT lab study questions and Answers

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what is the purpose of performing the DAT procedure? - ANSWER used to determine if red cells have been coated in vivo with immunoglobulin, complement or both. what does a positive DATE indicate? - ... ANSWER indicates that red cells are coated with protein in-vivo what 3 reagents may be used in the DAT procedure? - ANSWER polyspecific IgG, C3d monospecific IgG or C3d what is the sample of choice for the DAT? Why? - ANSWER whole blood collected in an EDTA tube because it prevents in-vitro fixation of complement. the DAT is used to assist in hemolysis associated with what 4 clinical conditions: - ANSWER HDFN autoimmune hemolytic anemia red cell sensitization transfusion rxns what 3 items in the pt history are crucial in determining the clinical significance of a positive DAT? - ANSWER pts diagnosis transfusion and pregnancy hx recent/current medications state the principle of the DAT procedure - ANSWER the detection of abs that attached to red cells in-vivo what ab class is involved in HDFN? - ANSWER IgG what is the source of the specimen used for the DAT on newborns? - ANSWER cord blood sample what is Wharton's Jelly? - ANSWER A gelatinous substance that provides insulation and protection within the umbilical cord what problems will contamination of the cord blood sample with Wharton's Jelly cause? - ANSWER nonspecific agglutination of red cells, can cause a false positive result list 3 types of HDFN from mildest to severe and state the ab specificity involved in each - ANSWER 1. ABO: most common, mild, group A/B 2. Anti-D: most severe [Show More]

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