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SEYED PET FINAL QUESTIONS

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SEYED PET FINAL QUESTIONS 1. Which radionuclides are possible radioactive contaminants in the eluent of an 82Rb generator? A. 82Sr and 85Sr B. 82Sr and82Zr C. 82Zr and85Zr D. 82Sr and 87Sr - ANS - A 2. Negative ion PET cyclotrons accelerate which of the following types of particles? A. Protons B. Negatively charged hydrogen atoms C. Negatively charged neutrons D. Negatively charged protons - ANS - B 3. 18F is labeled to glucose using a chemical method known as _ . A. electrophilic substitution B. base hydrolysis C. mannose triflate hydrolysis D. nucleophilic substitution - ANS - D 4. The bombarding particles used for the nuclear reactions that occur in a cyclotron must have an energy of at least _ MeV. A. 3 B. 5 C. 8 D. 10 - ANS - C 5. The most common irradiation process of producing 18F with a 109.75-minute half-life is A. 18O(p,alpha)18F B. 160(p,pn)18F C. 16O(p,alpha)18F D. 180(p,n)18F - ANS - D 6. Any product with a half-life greater than _____ minutes must pass quality control testing before it can be released for patient use. A. 10 B. 20 C. 30 D. 60 - ANS - B 7. As specified in the USP, 18F-FDG must have a labeling efficiency of greater than_______. A. 85% B. 90% C. 95% D. 98% - ANS - B/C 8. Which of the following quality control tests for 18F-FDG CANNOT be performed before patient use? A. Radiochemical purity B. Radionuclidic purity C. pH D. Sterility - ANS - D 9. The initial precursor molecule for producing 18F-FDG is ___________ . A. mannose triflate B. dibutylboron triflate C. trifluoroacetic acid D. methyl triflate - ANS - A 10. Because of the high amount of radioactivity, the production of PET radiopharmaceuticals must be done in lead-shielded hot cells and with an automated system called a __________ . A. cyclotron B. synthesis module C. reactor vessel D. Kryptofix 222 - ANS - B 1. A patient needs the administration of 12 mCi 18F-FDG and the current concentration of 18FFDG is 8.3 mCi/mL. How much volume should be prepared? A. 0.69 mL B. 0.95 mL C. 1.44mL D. 2.03 mL - ANS - C 2. The -weight of a patient is 134 Ib and the physician has prescribed 0.14 mCi/kg for this procedure. How much activity should be prepared? A. 7.5 mCi B. 8.5 mCi C. 14.3mCi D. 18.7mCi - ANS - B 3. 18F-FLT is helpful in patients with cancer because the uptake mechanism demonstrates the rate of __________ . A. blood flow B. fatty acid metabolism C. tumor hypoxia D. cellular proliferation - ANS - D

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