Chronic - ANSWER mature cells
what kind of cells are CLL? - ANSWER neoplastic disorder of monoclonal mature-appearing lymphocytes
what age group CLL affected? - ANSWER median age is 60 years
what is the M:F? - A
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Chronic - ANSWER mature cells
what kind of cells are CLL? - ANSWER neoplastic disorder of monoclonal mature-appearing lymphocytes
what age group CLL affected? - ANSWER median age is 60 years
what is the M:F? - ANSWER 2:1
What region of the world? - ANSWER western countries
Are most patients asymptomatic when they come in? - ANSWER yes, 40% are asymptomatic
what are the sites involved? - ANSWER peripheral blood/BM/lymph nodes/liver/Spleen/occasional extranodal sites- skin, breast, ocular adnexae
what are the clinical findings associated? - ANSWER most are asymptomatic
what are some of the symptoms associated with CLL? - ANSWER weakness, east fatigability, weight loss
what are some of the symptoms you see as the disease progresses? - ANSWER the disease as it progresses- it develops fever, night sweats
what happens when you disruption of the normal immune function due to CLL? - ANSWER inc viral/bacterial infections, pneumoniae, osteomyelitis
and it is primarily because of disruption of the normal immune function
Where are lymphadenopathy? - ANSWER cervical/supraclavicular
Describe the lymph nodes involved? - ANSWER they are usually discrete, freely movable and non-tender
Why does one have splenomegaly/hepatomegaly? - ANSWER due to infiltration by tumor.
what is the amount of lymphcytes you see in the peripheral blood? - ANSWER >5000/uL
"soccer balls" - ANSWER small mature appearing lymphocytes- CLL
what are smudge cells - ANSWER smudge cells- artificially ruptured lymphocytes
CLL - ANSWER soccerball
smudge cells
why are "smudge cells" - ANSWER the CLL cells are very fragile- and due to that they get smeared.
what is lymphocytosis? - ANSWER thats when you have bone marrow aspirate thats greater than 30% lymphocytes
what is the morphological pattern found on bone marrow? - ANSWER intersitiial, nodular or diffuse
what kind of pattern is it when lymphoid cells are intermixed among normal marrow? - ANSWER interstitial
what kind of pattern is it when the lymphoid cells come from noduleS? - ANSWER nodular pattern
what kind of pattern is it in CLL when lymphoid forms have taken over the marrow? - ANSWER diffuse
what is CLL - ANSWER thats when lymphocytes are round nuclei, clumped, chromatin and scant cytoplasm and they contain proliferation centers
which one is worse prognosis? - ANSWER diffuse pattern
which is one is best? - ANSWER nodular
what is the Hgb? Thrombocytopenia, what kind of test is it positive for? and what levels are increased? - ANSWER Hgb-<10 g/dL
Thrombocytopena- <100 k/uL
DAT- autoimmune manifestation- hemolytic anemia
B-2-microglobulin- these levels are elevated.
what cytogenetics are associated with poor prognosis? - ANSWER deletion of 13q, 11q, 17p, trisomy 17
11-13 and 17
how many cases have abnormal karyotypes? - ANSWER 80% have abnormal karyotypes
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