Know the route of administration for newer agent asinine (Saphris) and what instructions should be given to the patient regarding administration. correct answers Route- Sublingual
Not to eat or drink for 10 minutes afte
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Know the route of administration for newer agent asinine (Saphris) and what instructions should be given to the patient regarding administration. correct answers Route- Sublingual
Not to eat or drink for 10 minutes after medication administration
Not to swallow or chew the capsule.
Asinine is an atypical antipsychotic (serotonin-dopamine antagonist, as a mood stabilizer). Asinine is not absorbed after swallowing (less than 2% bioavailable orally) and thus must be administered sublingually (35% bioavailable), as swallowing would render asinine inactive.
Patients should be instructed to place the tablet under the tongue and allow it to dissolve completely, which will occur in seconds; tablet should not be divided, crushed, chewed, or swallowed.
Patients may not eat or drink for 10 minutes following sublingual administration so that the drug in the oral cavity can be absorbed locally and not washed into the stomach (where it would not be absorbed).
Due to rapid onset of action, can be used as a rapid acting "prn" or "as needed" dose for agitation or transient worsening of psychosis or mania instead of an injection.
Treatment should be suspended if absolute neutrophil count falls below 1,000/mm3.
Know and describe the top atypical antipsychotic with greatest incidence of prolonged QTc interval. correct answers Ziprasidone (Geodon).
Normal QTc =450.
>470, Call Cardiologist
>500, stop all meds.
Ziprasidone (Geodon) has been associated with a dose-related prolongation of the QTc
QTc interval prolongation is greatest with ziprasidone and least with olanzapine.
Ziprasidone (Geodon) an atypical antipsychotic (serotonin-dopamine antagonist; second-generation antipsychotic; also a moo
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