Adenohypophyseal Physio Correct Answer: - 3 func anat components = hypoth, adenohypophysis (ant pit), periph endoc gl/tiss
- hypoth secr 2 horm types to hypoth-hypoph port sys in med emin = rel horms (RH, liberins) & r
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Adenohypophyseal Physio Correct Answer: - 3 func anat components = hypoth, adenohypophysis (ant pit), periph endoc gl/tiss
- hypoth secr 2 horm types to hypoth-hypoph port sys in med emin = rel horms (RH, liberins) & rel-inhib horms (IH, statins)
w/ hypoth-hypoph port sys carrying horms to ant pit
Synthesis & Regulation of Growth Hormone (GH, somatotropin) Correct Answer: - synth by ant pit somatotropes (30-40% ant pit c)
- +by hypoth GHRH & Dopa
- -by GH, IGF-1, hypoth GHIH/somatostatin
Receptor, Target Organs, Peripheral Hormone Released by GH Correct Answer: -GH-r = tyr kin-assoc R, memb JAK/STAT superfam
- Targets = liv, bone, musc, adip, kidney
- Periph horm = IGF-1
Physiologic & Pharmacologic Stimulation of GH Correct Answer: - Physio = GHRH, ghrelin, ADH, GABA, NE, Dopa, serot, estrog, sleep, stress, exerc
- Pharm = alpha-ag, BB, Dopa ags (ie. Bromocriptine), GABA ag
Physiologic & Pharmacologic Inhibition of GH Correct Answer: - Physio = somatostatin, elev IGF-1, GH, progest, GCs, postprand hypergly, elev FFAs
- Pharm = Dopa antag, alpha antag, beta ag, serot antag
General Effects of GH Correct Answer: (+) visc+sk growth, lipolysis, prot synth, IGF-1 prod --> suppr liv gluc prod, incr periph gluc util, inhib insul secr
(-) insul sensit --> hypergly
Features of GH Deficiency (hypopituitarism) in Children & Adults Correct Answer: - Children & adols = congen/acq def --> growth stunt, dwarf, +fat-musc mass ratio, hypogly by unopp insul
- Adult = -lean bod mass, +body fat to obes, -musc mass, asthenia (phys weak), -BMD, dyslip, -CO
Examples, MOA, Administration, PK of Recombinant human GH (rhGH) Correct Answer: incl Somatrem (protropin) & Somatropin (10 diff brand names)
- MOA = mimic GH physio actions
- Admin = 6-7x/wk
- PK = peak pl levs 2-4hrs w/ 36hr persis
- Route = IM & SQ, must be injec b/c is prot & not abs orally
Indications for rhGH Correct Answer: - Children & Adols = idiop short stat (ISS); **many growth fail indics NOT assoc w/ GH def**
- Adults = AIDS-assoc wasting
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