DSM5 Criteria for Major Depressive Disorder Correct Answer: 1+ maj depr eps w/o hx man/hypoman
- 5+ SIGECAPS sx nearly everyday 2w per w/ change from prev func lev
- MUST impair func/cause subst distr
- 1 sx MUST be
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DSM5 Criteria for Major Depressive Disorder Correct Answer: 1+ maj depr eps w/o hx man/hypoman
- 5+ SIGECAPS sx nearly everyday 2w per w/ change from prev func lev
- MUST impair func/cause subst distr
- 1 sx MUST be depr mood/anhed
SIGECAPS sx of MDD Correct Answer: - Suic ideation w/ w/o plan; suic att; recur thoughts of death
- Interest (loss int/pleas in activs; anhed)
- Guilt (inappr/excess, feeling worthlessness)
- Energy decr
- Conc decr; diff making decis
- Appet ch (typ decr, change 5% wt from basel)
- Psychomot agit/retard
- Sleep impair (typ insom but maybe hypersom)
Pathophysiology of MDD (Biogenic Amine Hypothesis) Correct Answer: results from monoam NT def cort+limb brain areas
- Dopa, 5-HT, and/or NE neurotransm abnorms --> decr cort resp to emo activ --> affective dysf+depr w/ impair serot NT
- Noradr fibs proj from loc cerul to cer cort+dopa fibs innerv nuc accumb also reg mood
- monoam def --> upreg postsynR
Monoamine NT Neuronal Regulation & Antidepressant MOA Correct Answer: interf w/ transp mols inhib NT reup incr amts in synapse
Monoamine System Feedback Correct Answer: DO NOT func indep
ie. med enh NE transm may sec alter 5-HT+Dopa activ & 5-HT known to inhib NE+Dopa rel in cert brain areas
NE Synthesis, Binding, Reuptake Correct Answer: - tyramine conv to NE, stored in vesics/degr by MAO
- binds postsyn alpha/beta adrenR; binds/agonizes presyn alpha2R inhib NE rel
- Recyc back presyn by NET transp
Serotonin Synthesis, Binding, Reuptake Correct Answer: - tryp conv to 5HT
- Binds many postsyn/presynR --> activ presynR to decr neur firing
- SERT transp for reup
Problems w/ Monoamine Hypothesis Correct Answer: antideps rap changing monoam concs have delayed onset to effic --> effs maybe sec to alter R dens/sensits OR sec sig PW (ie. inositol synth disr in bipol disord)
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