Totect
Anecdote for Doxorubicin
Warm Compress
Plant alkaloids and etoposide
Bleomycin
bad for the lungs
Leucovorin
potentiates the effects of 5-FU and decreases the effect of MTX
Calvert F
...
Totect
Anecdote for Doxorubicin
Warm Compress
Plant alkaloids and etoposide
Bleomycin
bad for the lungs
Leucovorin
potentiates the effects of 5-FU and decreases the effect of MTX
Calvert Formula Components
Area under the curve (AUC)
Carboplatin
Creatinine Clearance
Aromatase Inhibitors
used for postmenopausal women- osteoporosis
Vesicant Administration
Prior to non-vesicant drugs
Through a central line or small gauge peripheral line
+ blood return
Cytarabine
Assess gross motor movement and coordination
Capillary Leak Syndrome S/S
HYPOtension and decreased UOP
Most feared symptom of cancer
nausea/vomiting
For CD20+ NHL
Rituximab
S/E Anti-angiogenesis agents
bleeding events
delayed wound healing
thrombotic events
Asparaginase
Test dose is given prior
Hypersensitivity Drugs
Rituxan
Trastuzumab
Paclitacel
Cabazitaxel
Cytostatic Agents
slow the growth of cancer cell
Cytotoxic Agents
kill cancer cells
Bone Pain
Common side effect of colony stimulating
Cisplatin
Can cause ototoxicity and renal toxicity
Alcohol
Solvent used in Carmustine
Mesna
Used to prevent hemorrhagic cystitis
Hypomagnesaemia
common side effect of arsenic trioxide (Trisenox)
Vincristine
Neurologic Toxicity
-constipation
-cranial nerve dysfunction
-peripheral neuropathy
Diarrhea
associated with
- 5-FU
-Idarubicin
-Ironetecan
Provenge
Cancer treatment vaccine
Temazolamide
crosses the blood brain barrier
Biologic Response Modifier
MOA: modifies the relationship between a tumor and the host immune system
Interferon
Black Box Warning: Depression
Consent Needed
-Initiating new therapy
-adding chemo drug to regimen
ANC
(poly+bands)WBC
1500
Neutropenic Level
Thalidomide
cannot be given to pregnant women
Doxorubicin
urine=red
IV Push Chemo
Always administer through free flowing IV
Ifosfamide
watch urine for blood
Steps to Take of a Chemo Spill
1. ensure safety of pt and contain the spill
2. put on protective apparel from spill kit and place chemo bag in waste container
3. place contaminated linens in linen bag and mark per policy
4. wash your hands & document
Flare Reaction
transient redness along the vein without pain
Delayed Nausea
occurring after chemo
Oxaliplatin
Cod sensitivity
Myelosuppression
Most common dose limiting toxicity in cancer patients
Paclitaxel
assess neurotoxicity- have pt pick up coin
Tumor Lysis Syndome
1. hyperkalemia
2. hyperphosphatemia
3. hyperuricemia
4. hypocalcemia
IL2
risk of hypotension
Atropine
used to treat early diarrhea from Irinotecan (Camptosar)
Capecitibe
risk of hand and foot syndrome
Extravasation
possible with positive blood return
Premeds foor Pemetrexed
B12 and folic acid
Rapid infusion of Etoposide (S/E)
hypotension
Hormonal Therapy
class of drug prescribed for a pt that is estrogen or progesterone receptor positive
Methotrexate
given intrathecally
Fludarabine
physicians will often treat prophylactically with antibiotics when this is prescribed
Radiosensitizer
Gemcitabine
3 Hormonal Therapies
-anastrozole (Armidex)
-biculatamide (Casodex)
-Tamoxifen (Soltaox)
3 Drugs can cause cardiac toxicity
doxorubicin
traztuzmab (herceptin)
pertuzamab (perjeta)
Chemo brain
not an abnormal side effect of some cancer therapies
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