Pharmacology > QUESTIONS & ANSWERS > MIDTERM STUDY GUIDE FLASHCARDS FOR ADVANCED PHARMACOLOGY NURSING 6521 LATEST SOLVED UPDATE 2022 (All)
MIDTERM STUDY GUIDE FLASHCARDS FOR ADVANCED PHARMACOLOGY NURSING 6521 LATEST SOLVED UPDATE 2022
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the study of the movement of drugs within the body - ANS-pharmacokinetics the study of the effects of drugs and their mechanism of action - ANSpharmacodynamics describes what the body does to the d... rug through absorption, distribution, metabolism, and excretion - ANS-pharmacokinetics describes what the drug does to the body - ANS-pharmacodynamics What is the impact of Cirrhosis on drug levels and dosing? - ANS-Because medications with a low extraction ratio (e.g., warfarin, phenytoin, carbamazepine, and lorazepam) rely heavily on the metabolic capacity of the liver for intrinsic clearance through CYP 450 enzymes, these medications will be impacted more significantly.Nearly 30% of patients with cirrhosis suffer adverse drug reactions or hepatoxicity if these risk factors are not considered or monitored closely. So Close monitoring of liver functions and doses may need to be reduced due to risk of hepatoxicity. What is the impact of protein binding on drug levels and dosing? - ANS-Decreased plasma protein binding leads to an increase in free plasma fraction causing an increase in volume of distribution and a shorter elimination half life. The increase in the apparent volume of distribution and the shorter elimination half life cause a decrease in total plasma concentration. what is the impact of drug interactions on drug levels and dosing? - ANSWhat is the impact of half-life on drug levels and dosing? - ANS-For drugs with short half-life the dosing interval must be correspondingly short. If a drug has a long half-life a long time can separate doses without loss of benefit. The actual amount of drug lost in one half life depends on how much drug is present the tire drug in the body, the larger the amount of drug lost in one half-life continues... [Show More]
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