IV Induction Barry
Barry IV Induction Agents
Question Answer
What are the overall mechanisms
of action(3) of the barbiturates?
Depresses the reticular
activating system,
enhances the inhibition
of GABA, and inhib
...
IV Induction Barry
Barry IV Induction Agents
Question Answer
What are the overall mechanisms
of action(3) of the barbiturates?
Depresses the reticular
activating system,
enhances the inhibition
of GABA, and inhibits
the transmission of
excitatory
neurotransmitters such
as acetylcholine.
What is the reticular activating
sytem responsible for?
Maintenance of
wakefulness
What is the most common
inhibitory neurotransmitter in the
brain?
GABA
What is the most common
excitatory and overall
neurotransmitter in the brain?
Glutamate
What are some of the
characteristics of IV induction
agents?
Rapid induction of
anesthesia, usually
highly lipophilic, rapid
onset of action, rapid
recovery due to
redistribution.
What makes thiopental so highly
lipid soluble?
The addition of a
sulfur group
What is the resulting percentage
solution after Thiopental is
reconstituted?
2.5%, which is
25mg/ml.
What is the induction dose of
Thiopental? 3-5 mg/kg IV
What is the reconstituted solution
and how many mg/ml is
Methohexital?
1%, which is 10mg/ml
Which IV anesthetics should you
not give to a patient with a
history of seizures?
Etomidate and
Methohexital
What is the IV induction dose of
Methohexital? 1-2 mg/kg IV
What is the rectal dose of
Methohexital?
25 mg/kg of a 10%
solution
How do the benzodiazepines
work?
Enhance the inhibitory
effects of GABA.
What are the benzodiazepines
used for?
Sedation, amnesia,
anxiolysis, and
anticonvulsants.
Why are
Diazepam/lorazapam/etomidate
painful when given IV or IM?
It is mixed with
propylene glycol
because it is insoluble
in water.
What is a problem with
Diazepam?
It undergoes
metabolism to an
active metabolite.
What is the preop IV sedation
dose of Diazepam? 0.02-0.04 mg/kg IV
What are some benefits of giving
Midazolam instead of Diazepam?
Elimination half time
is 1-4 hrs vs that of
valium which is 21-37
hrs, NO active
metabolites, and
causes less cardiac
depression than
valium.
What is a great benefit of giving
Versed?
It causes anterograde
amnesia
What is the IV Midazolam dose
for sedation?
0.01- 0.1 mg/kg IV for
sedation
What is the IV Midazolam dose
for induction?
0.1-0.2 mg/kg IV for
induction in cardiac
patients
What are some benefits of giving
Midazolam instead of Diazepam?
Elimination half time
is 1-4 hrs vs that of
valium which is 21-37
hrs, NO active
metabolites, and
causes less cardiac
depression than
valium.
What is a great benefit of giving
Versed?
It causes anterograde
amnesia
What is the IV Midazolam dose
for sedation?
0.01- 0.1 mg/kg IV for
sedation
What is the IV Midazolam dose
for induction?
0.1-0.2 mg/kg IV for
induction (Usually
only used in cardiac
patients for induction)
What is Etomidate's mechanism
of action?
Produces CNS
depression primarily
by enhancing effects of
GABA.
What are some potential
problems that may occur due to
the administration of Etomidate?
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