Health Care > EXAM > NUR-641E Advanced Pathophysiology and Pharmacology for the Nurse Educator With Complete Solutions 20 (All)
NUR-641E Advanced Pathophysiology and Pharmacology for the Nurse Educator With Complete Solutions 2023
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Pharmacokinetics - Involves ADME (absorption, distribution, metabolism and elimination). Absorption: absorption from the administration site either directly or indirectly into the blood/plasma. ... Distribution: reversibly or irreversibly move from the bloodstream into the interstitial and intracellular fluid. Metabolism: bio-transformed via hepatic metabolism or by other tissues. Elimination: lastly, the drug & its metabolites are eliminated from the body The route of administration with the highest bio-availability is - Intravenous; putting entire dose into a patient's vein and bypassing absorption. Intravenous route avoids first-pass metabolism in the liver. rectal administration disadvantages - variable and erratic absorption Steady state (SS) - is usually reached within 4-5 half-lives of a drug The half-life of a drug is defined as - how long it takes for half the drug to be excreted from the body Half-life of a drug - Determines how frequently the drug must be administered Predicts how long toxic effects can last [Show More]
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