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NURS 615 - Pharm Exam 3 Study Guide.

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NURS 615 - Pharm Exam 3 Study Guide/NURS 615 - Pharm Exam 3 Study Guide. Colchicine – is an anti-inflammatory (gout) = can treat and prevent gout attacks, also Behcets syndrome  MOA- Inhibits mic... rotubule formation at cellular level, limits neutrophil migration and aggregation to tissues, and inhibits mitosis o Decreases inflammatory repose to urate crystal deposits—used in acute attacks  SE = always causes diarrhea, other GI symptoms include upset stomach, N/V/D, abdominal pain  Taking with food helps ↓ GI side effects  Check renal function before and during tx (BUN, creatinine) o Impaired renal/hepatic function requires decreased doses/frequency to prevent s/e including neuromyopathic symptoms  Interacts with NSAIDS—AVOID  Report: proximal muscle weakness, myalgia and neuropathy (usually resolves in 204 weeks after stopping med)  Lower dose (1.2 mg followed by 0.6 mg one hour later) is as effective as high dos [Show More]

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