NURS 615 - Pharm Exam 3 Study Guide/NURS 615 - Pharm Exam 3 Study Guide. Colchicine – is an anti-inflammatory (gout) = can treat and prevent gout attacks, also Behcets syndrome MOA- Inhibits mic... rotubule formation at cellular level, limits neutrophil migration and aggregation to tissues, and inhibits mitosis o Decreases inflammatory repose to urate crystal deposits—used in acute attacks SE = always causes diarrhea, other GI symptoms include upset stomach, N/V/D, abdominal pain Taking with food helps ↓ GI side effects Check renal function before and during tx (BUN, creatinine) o Impaired renal/hepatic function requires decreased doses/frequency to prevent s/e including neuromyopathic symptoms Interacts with NSAIDS—AVOID Report: proximal muscle weakness, myalgia and neuropathy (usually resolves in 204 weeks after stopping med) Lower dose (1.2 mg followed by 0.6 mg one hour later) is as effective as high dos [Show More]
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