*NURSING > EXAM REVIEW > FULL NR 566 2020/2021 Study Guide Drugs Affecting the Reproductive System (All)
FULL NR 566 2020/2021 Study Guide Drugs Affecting the Reproductive System
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• Antiandrogens: several different categories o Androgen hormone inhibitors (5-alpha-reductase inhibitors) ▪ Drugs: Finasteride (Propecia, Proscar) and dutasteride (Avodart) ▪ MOA: Block conv ... ersation of testosterone to dihydrotesterone ▪ Used to Tx BPH ▪ PSA levels and digital prostate examination are required monitoring for men on these agents ▪ Finasteride (Propecia, Proscar): • Extensive hepatic metabolism • BPH: 5mg/day, 6 to 12 months of therapy until therapeutic response o Regression of prostate size increased urinary flow, and improve BPH symptoms • Approved for Male pattern baldness: 1 mg/day, three months until results • Stopping the drugs reverses the effect within 12 months • ADRs: decreased libido, impotence (can occur at both doses) ▪ Dutasteride (Avodart) • Inhibits both type 1 and 2 (5-alpha-reductase) • Peak clinical effect 6 to 12 months of therapy • Extensively metabolized in the liver (CYP3A4 and CYP3A5)• Used to Tx BPH • Absorbed through the skin, women who are pregnant or may become pregnant should not handle dutasteride capsules r/t risk of fet [Show More]
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