Chemistry > EXAM > MGMT411 Chapter 9 Test Bank 2023{Distinction level} (All)

MGMT411 Chapter 9 Test Bank 2023{Distinction level}

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what type of reaction is catalyzed by proteases - -hydrolysis -what metal iron is required by carbonic anhydrases for activity - -Zn2+ -What metal ion is frequently found in enzyme sites that ac... t on phosphate containing substrates - -Mg2+ -The catalytic mechanism of carbonic anhydrase, in which the substrate are simply oriented to stabilize the transition state, is called ______ - -catalysis by approximation -the mechanism of chymotrypsin involves the formation of an unstable ________- shaped intermediate that is stabilized by the oxyanion hole - -tetrahedral -in trypsin, the specificity pocket contains a/an _________ residue that binds to the positive charge of the K or R residue of that substrate - -aspartyl, aspartic, or D -The reaction center of most carbonic anhydrases in a zinc ion bound to water _______ residues of the enzyme - -histidine -In chymotrypsin, the tetrahedral intermediate transition state is stabilized by a structural feature referred to as the "___________________" hole. - -oxyanion -in proteases such as papain, a _________ residue is activated by hydrogen-bonding to a histidine residue - -cysteine -Myosins hydrolyze _____________ in a controlled manner and use the free energy of hydrolysis to promote conformational changes within myosin itself. - -ATP -Which amino acids in chymotrypsin are found in the active site and are participants in substrate cleavage - -His, Ser, Asp -how specificity is determined by chymotrypsin - -binding of the proper amino acid into deep pocket on the enzyme -Where does cleavage of the scissile bond by chymotrypsin occur? - -on the C-terminal side of a Phe or Trp residue [Show More]

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