NR 507 Midterm Exam Study Guide – Questions with Answers

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NR 507 Midterm Exam Study Guide – Questions with Answers NR 507 Midterm Exam Study Guide – Questions with Answers Epigenetics Defects in the encoding of histone-modifying proteins  Housekee ... ping Genes are vital to the function and maintenance of all the body’s cells. What characteristic is associated with these genes? They lack encoding histones  Mutations in the encoding of histone modifying proteins have been shown to influence the development of what congenital condition? Acephalous  Epigenetics refers to chemical modification that are made to what? Both the DNA and the histones  Signals to change or modify epigenetic tags are received from where? Contact with other cells, hormones and environmental factors.  What sort of molecule is responsible for transferring signals into cells to gen regulatory proteins? Proteins  Mutations in the encoding of histone-modification proteins have been shown to influence the development of what congenial condition? Heart Disease Epigenetics and its role on human development  Research has provided support for the theory that epigenetic modification can result from deficient in utero nutrition causing? Obesity, cardiovascular disease, and diabetes  During which stage of human development does the role of epigenetics have the greatest impact on the development of epigenetic abnormalities? In utero  The difference between DNA sequence mutations and epigenetic modifications is? Epigenetic modification can be reversed.  Research has provided support for the theory that epigenetic modification can result from deficient in utero nutrition causing which chronic disease? Obesity, cardiovascular disease and diabetes Totipotent cells and its ability to differentiate into any type of cell  Which embryonic stem cell characteristic is referred to as a totipotent? Ability to differentiate into any type of somatic cell  Examples of two totipotent cells are? A zygote and Cells in the early embryo up to 5 days  What is a Totipotent cell? Totipotent cells are cells that are able to develop into any type of cell found in the body.  Are all cells Totipotent cells?  No. Only the fertilized egg and the cells produced by the first few cell divisions (in the Embryonic Development phase) are Totipotent cells. Prader-Willi syndrome and Angelman syndrome?  What characteristic of Prader-Willi syndrome is not a characteristic of Angelman syndrome? it is inherited from the father  A child with Prader-Willi syndrome has been hospitalized. Which assessment findings does the nurse expect with this syndrome? Insatiable hunger  The nurse is examining an 8-year-old boy with chromosomal abnormalities. Which sign or symptom suggests the boy has Angelman syndrome?  Observation shows jerky ataxic movement similar to a puppet's gait. Cellular Proliferation 5-Azacytidine and the treatment of cancer  What is 5-azacytidine? Nucleoside analog able to be incorporated into RNA & DNA  5- Azactytide has demonstrated promise in the treatment of which form of cancer? Pancreatic the role of inactive MLH1 in the development of some forms of inherited colon cancer  What is the role of inactive MLH1 in the development of some forms of inherited colon cancer? DNA damage is left unrepaired Effects of ethanol on neural stem cells ability to differentiate into functional neurons-  Research has demonstrated that neural stem cells have an impaired ability to differentiate into functional neurons when subjected to? Ethanol Inflammation as an etiology for cancer-note conditions in which this may occur  What chronic inflammatory conditions can increase risk for cancer? HIV, hepatitis, h-pylori, bronchitis, pancreatitis Cancer In terms of epigenetic modifications, the role of environmental stressors .............continued [Show More]

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