An elderly patient is suffering from depression was given St. John's Wort.
Which of the following drugs if administered concomitantly will have a clinically significant interaction?
A. Simvastatin
B. Salbutamol C. Ser
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An elderly patient is suffering from depression was given St. John's Wort.
Which of the following drugs if administered concomitantly will have a clinically significant interaction?
A. Simvastatin
B. Salbutamol C. Sertraline
D. Gliclazide
The high prevalence of osteoporosis in the elderly results which incidence in geriatric population?
A. Hyperkalemia B. Bone fractures
C. Urinary retention
D. Memory impairment
An elderly man presented to the Emergency Room with dizziness, altered consciousness, respiratory depression and rhabdomyolysis. He was recently prescribed a medication for inability to sleep.
Which is the most likely drug toxicity?
A. Benzodiazepines
B. Acetaminophen
C. Salicylate
D. Opioid
A man weighs 78 Kg is to be administered one gram vancomycin intravenously every 12 hours for seven days. The half-life of vancomycin is approximately eight hours and volume of distribution is approximately 1 L/ Kg. What is the expected average steady state plasma concentration in mg/L of vancomycin?
A. 5
B. 7 C. 13
D. 19
Ans: Cpss=??????.??.?=1000 ??78?0.0867?12=12.3 ~13mg/L
An antibiotic has an elimination rate constant of 0.05 per hour and apparent volume of distribution of 0.6 L/Kg. What will be the clearance value in a 75 Kg adult?
A. 1 .75 L/hrs B. 2.25 L/hrs
C. 3.55 L/hrs
D. 4.25 L/hrs
Ans: Cl =Vd.ke = (0.6 X 75) X 0.05 = 2.25 L/hrs
A 45 year-old patient of rheumatoid arthritis has been prescribed naproxen 250 mg enteric coated tablets twice daily. The elimination half-life of naproxen is 12 hours. How much time it would take to reach the 95% of steady state plasma concentration?
A. 22.3 hrs
B. 38 .7 hrs C. 51 .6 hrs
D. 66.5 hrs
Ans: Time to reach 95% steady state conc. require 4.3 half-lives (t1/2) 4.3 X 12 = 51.6 h
A 35 year-old individual is receiving 20 mg of propranolol hydrochloride four times daily as a prophylaxis to migraine attacks. If the drug has only 25% bioavailability due to extensive first pass effect. What amount of the drug reaches the systemic circulation after each dosing?
A. 2.5 mg B. 5.0 mg
C. 7.5 mg
D. 10 mg Ans: F = ???? ?? ???? ????????? ?? ??????????? ???? ?? ?ℎ? ???? ?????????????= Mass = 25% X 20 mg = 5 mg
An NSAID has an oral dose of 200 mg, bioavailability of 80% and elimination half-life of four hours. How much drug will be remaining in the body after 12 hours?
A. 20 mg
B. 40 mg
C. 60 mg
D. 80 mg
Ans: Mass = 200X80%=160mg
Total hrs. =12h
(After 4h will reach its half “80mg” after another 4 h “40 mg” after another 4h “20 mg”)
Which one of the medications can be dispensed without prescription?
A. Insulin vials
B. Metoprolol 50 mg tablet C. Ibuprofen 400 mg tablet
D. Aripiprazole 10 mg tablet
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