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Review Questions
MCGRAW HILL ACCESS SUPPORT SUBSCRIBE edgar harvey
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Access Provided by: SOUTH UNIVERSITY SAVANNAH 5010
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33.1 33.1
AA
✓✓ BB
CC DD EE
Glomerulonephritis (Acute Poststreptococcal) >
Quiz Results Quiz Results
Your Score: 100 % Your Score: 100 %
You answered 3 of 3 questions correctly.
Question Question 1: 1: Correct Correct
A 6-year-old boy presents with a new onset of oliguria and hematuria shortly a!er he has
recovered from an untreated sore throat. Additional workup finds hypertension, periorbital
edema, and impaired renal function with slightly increased amounts of protein in the urine.
A renal biopsy most likely would reveal electron-dense deposits in which of the following
sites?
Between the basement membrane and endothelial cells of the glomeruli
Between the basement membrane and epithelial cells of the glomeruli
Between the basement membrane and epithelial cells of the proximal tubules
Within the mesangium of the glomeruli
Within the juxtaglomerular apparatus
✓✓ AA
BB CC DD EE
The correct answer is BB. You answered BB.
Explanation:
B. B. Acute di"use proliferative glomerulonephritis most commonly presents in children a!er a
group A β-hemolytic streptococcal infection; this explains the other name of this disorder:
acute poststreptococcal glomerulonephritis. Children develop signs of the nephritic syndrome
with hematuria, mild periorbital edema, and increased blood pressure. This disorder is
characterized by irregular larger subepithelial (between the basement membrane and
epithelial cells) electron-dense deposits.
67 67% of users answered correctly.
Source: Case Files: Pathology 2e
Question Question 2: 2: Correct Correct
Which of the following is the histologic hallmark for the diagnosis of rapidly progressive
glomerulonephritis?
Crescents within the glomeruli
Fibrinoid necrosis of the e"erent arterioles
Fibromuscular hyperplasia of the a"erent arterioles
"Spike and dome" appearance of the glomerular basement membrane
"Tram-track" splitting of the glomerular basement membrane
The correct answer is AA. You answered AA.
Explanation:
A. A. Rapidly progressive glomerulonephritis is characterized histologically by the presence of
crescents within glomeruli (crescentic glomerulonephritis). A crescent, which is defined as
having at least three layers of cells between the visceral and parietal epithelium, is composed
of visceral and parietal epithelial cells, inflammatory cells, and fibrin. The three basic types of
RPGN, defined by the immune pathomechanism, are anti-GBM disease (linear immune
deposits), immune-complex–mediated disorders (granular immune deposits), and the pauciimmune type (very few immune deposits).
67 67% of users answered correctly.
Source: Case Files: Pathology 2e
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33.3 33.3
✓✓ AA
BB CC DD EE
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Question Question 3: 3: Correct Correct
A renal biopsy from an adult who presented with progressive renal failure and hematuria
reveals linear deposits of IgG within the glomeruli. Which of the following types of
autoantibodies is most likely to be present in this individual?
Anti-basement membrane antibodies
Anticentromere antibodies
Anti–-double-stranded DNA antibodies
Antimitochondrial antibodies
Anti–smooth muscle antibodies
The correct answer is AA. You answered AA.
Explanation:
A. A. Type I rapidly progressive glomerulonephritis is characterized by the finding of linear
deposits of IgG and C3 within the glomerular basement membrane using
immunofluorescence. Patients usually present with massive hemoptysis and acute renal
failure. Most patients are found to have Goodpasture disease, in which autoantibodies to the
glomerular basement membrane are present. These autoantibodies are directed against the
noncollagenous portion of type IV collagen.
71 71% of users answered correctly.
Source: Case Files: Pathology 2e
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