A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This
is critical toprescribing because:
• Distribution of drugs to target tissue may be affected.
• The solubility of the drug will not m
...
A patient’s nutritional intake and laboratory results reflect hypoalbuminemia. This
is critical toprescribing because:
• Distribution of drugs to target tissue may be affected.
• The solubility of the drug will not match the site of absorption.
• There will be less free drug available to generate an effect.
• Drugs bound to albumin are readily excreted by the kidneys.
2. Drugs that have a significant first-pass effect:
• Must be given by the enteral (oral) route only
• Bypass the hepatic circulation
• Are rapidly metabolized by the liver and may have little if any desired action
• Are converted by the liver to more active and fat-soluble forms
3. The route of excretion of a volatile drug will likely be the:
• Kidneys
• Lungs• Bile and feces
• Skin
4. Medroxyprogesterone (Depo Provera) is prescribed intramuscularly (IM) to
create a storagereservoir of the drug. Storage reservoirs:
• Assure that the drug will reach its intended target tissue
• Are the reason for giving loading doses
• Increase the length of time a drug is available and active
• Are most common in collagen tissues
5. The NP chooses to give cephalexin every 8 hours based on knowledge of the drug’s:
• Propensity to go to the target receptor
• Biological half-life
• Pharmacodynamics
• Safety and side effects
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6. Azithromycin dosing requires that the first day’s dosage be twice those of the
other 4 days of theprescription. This is considered a loading dose. A loading
dose:
• Rapidly achieves drug levels in the therapeutic range
• Requires four- to five-half-lives to attain
• Is influenced by renal function
• Is directly related to the drug circulating to the target tissues
7. The point in time on the drug concentration curve that indicates the first sign of a
therapeutic effectis the:
• Minimum adverse effect level
• Peak of action
• Onset of action
• Therapeutic range
8. Phenytoin requires that a trough level be drawn. Peak and trough levels are done:
• When the drug has a wide therapeutic range
• When the drug will be administered for a short time only
• When there is a high correlation between the dose and saturation of receptor
sites
• To determine if a drug is in the therapeutic range
9. A laboratory result indicates that the peak level for a drug is above the minimum
toxic concentration.
This means that the:
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