Pharm 530 Exam 1 Study Guide
Objectives: Module 1: Intro to Pharmacology and Pathophysiology
1 Discuss the four main processes that make up pharmacokinetics.
2. Discuss the advantages/disadvantages of the various te
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Pharm 530 Exam 1 Study Guide
Objectives: Module 1: Intro to Pharmacology and Pathophysiology
1 Discuss the four main processes that make up pharmacokinetics.
2. Discuss the advantages/disadvantages of the various techniques of drug administration as they relate to pharmacokinetics.
3. Describe blood flow to tissues; the ability of a drug to exit the vascular system, and the ability of a drug to enter cells, and then discuss the characteristics of drug molecules that can alter these processes. Your description should include protein binding and factors that influence protein binding.
4. Describe the ultimate “goal” of drug metabolism. Discuss the general processes involved in drug metabolism and identify the major or vital organs in which most drug metabolism occurs.
5. Discuss the importance of understanding the time course of drug responses (plasma drug levels, single-dose time course, drug half-life, and drug levels produced with repeated doses).
6. Discuss the consequences of drug blood levels that fluctuate considerably or erratically between doses and describe how to identify such fluctuations.
7. Define pharmacodynamics and its relationship to the action of drugs on the body.
8. Discuss dose-response relationships, the effects drugs can produce, and the amount of drug needed to elicit an effect.
9. Discuss properties of drug-receptor interactions.
10. Describe how receptors function in the responses to many drugs and physiologic processes.
11. Differentiate drugs that are agonists, partial agonists, or antagonists.
12. Discuss inter-patient variability in drug responses.
13. Discuss the concept of a drug’s therapeutic index and its application and benefits to clinical practice.
14. Discuss the consequences of drug-drug interactions, the basic mechanisms of drug-drug interactions, and the critical steps in minimizing adverse drug-drug interactions.
15. Focus on the liver as an example of a drug-metabolizing system and explain why it is such a crucial organ in many drug-drug interactions.
16. Discuss the effect of food on drug absorption, on drug metabolism (e.g., grapefruit juice), and on drug toxicity and action, as well as the timing of drug administration with respect to meals.
17. Discuss side effect, toxicity, allergic reaction, idiosyncratic effect, iatrogenic disease, physical dependence, carcinogenic effect, and teratogenic effects of drugs.
18. Discuss organ-specific toxicity. (Focus on the liver as a drug-metabolizing system.)
19. Discuss the significance of body weight/composition.
20. Discuss age as a factor in medication administration.
21. Discuss the effects of kidney disease, liver disease, acid-base imbalance, and altered electrolyte status on drug responses.
22. Discuss bioavailability and other causes of variable absorption. Explain why differences in bioavailability are a significant concern with drugs that have a narrow therapeutic index.
23. Discuss the effects of diet (especially protein) on drug responses.
High protein diets can accelerate drug metabolism by stimulating enzymes within the liver.
24. Explain the differences in drug therapy and changes in pharmacokinetics and pharmacodynamics in extreme age groups (the very young and the very old.)
Module 1B: Fluids, Electrolytes, IV Fluids and intro to Renal Disease
1. Explain the factors that influence variation in drug responses
2. Describe considerations that affect drug therapy in pregnancy
3. Explain a teratogen and describe the most critical time that exposure can cause fetal problems
4. Broadly explain significance of the different categories of drugs in pregnancy.
5. Describe the significant differences in ADME in children
6. Describe the significant differences in ADME in older adults
7. Describe normal fluid distribution within the body
8. Explain concentration gradient and the difference in diffusion, osmosis, filtration, and active transport
9. Describe the makeup and differences in isotonic, hypotonic, and hypertonic solutions and the effect each has on human cells
10. Explain the importance of fluid intake and fluid loss as it relates to nursing care
11. Describe the effect of thirst on fluid maintenance
12. Explain in broad terms, the effect of the kidney on fluid and electrolyte balance
13. Describe the normal ranges of electrolyte values for adults
Normal Electrolyte Values for Adults
Sodium
Potassium
Chloride
Calcium (total)
Calcium (ionized)
Magnesium
14. Describe the major causes of water imbalance in the human
15. Describe different types of fluid losses and their causes
16. Explain "third spacing"
17. Describe different types of fluid excess and their causes
18. Describe the causes of edema and explain how edema is classified
19. Describe the major function of sodium and potassium in the human body
20. Describe the signs and symptoms of sodium, potassium, and calcium imbalance
21. Describe the uses of IV therapy
22. Describe the advantages and disadvantages of IV fluid therapy
23. Describe the potential complications of IV therapy
24. Explain why POTASSIUM is NEVER GIVEN AS A BOLUS
25. Explain when and why dextrose and water solutions are administered
26. Explain when and why saline solutions are administered
27. Describe the characteristics of normal urine
28. Describe the tests for renal functions
29. Explain the difference between acute and chronic renal failure
30. Describe the differences in PRErenal, INTRArenal and POSTrenal causes of kidney injury and give examples of their causes
31. Describe the phases of acute tubular injury
32. Define chronic renal failure
33. Explain how glomerular filtration is related to severity of renal failure
34. Describe the clinical symptoms and manifestations of early and late renal failure
35. Describe the effects of kidney disease on pharmacokinetics and pharmacodynamics
36. Describe the methods of renal replacement in chronic renal disease
37. Describe the role of diet in the management of chronic renal disease
38. Describe the effects of chronic kidney disease in children
39. Describe normal changes in the kidney of older adults
Module 2: Cell regulation, anemia, and blood and blood products will be introduced.
40. Describe the anatomy of a human cell and the function of the organelles
41. Name the phases of the cell cycle
42. Explain the phases of mitosis
43. Define hyperplasia, hypertrophy, atrophy, anaplasia, metaplasia, and dysplasia
44. Explains the differences between benign and malignant cells
Describe the characteristics of malignant cells
45. Describe three causes of cancer
46. Explain the role of viruses as a cause of cancer
47. Describe the tests used to diagnose cancer
48. Describe, in broad terms, four treatment modalities for cancer
49. Define anemia
50. Describe three nutritional causes of anemia
51. Describe the genetic and non-genetic causes of hemolytic anemia
52. Describe the causes of aplastic anemia.
53. Describe tests used for diagnosing anemia.
54. Describe the cellular components of blood. Look at chart-great description
55. Describe two functions of plasma
56. Describe the protein components of plasma and their function.
57. Explain the function of red cells, neutrophils, and granulocytes
58. Explain the purpose of blood transfusion
The purpose of blood transfusion is to:
59. Explain the differences in whole blood, packed red cells, platelets, fresh frozen plasma, and albumin transfusions and describe their purposes
Red cell components
60. Describe the potential complications of blood transfusion
61. Describe mechanisms to prevent transfusion complication
62. Describe tests used for diagnosing anemia
63. Describe in general terms the function of vitamins
64. List the fat soluble and water soluble vitamins
65. List at least two conditions caused by deficiency of Vitamin A and one condition caused by deficiency of each of the following: Vitamin D and Vitamin K
66. Describe food sources of Vitamin C and the B vitamins and describe what distinguishes Vitamin B12 from the rest of the B vitamins
67. Describe the major complication(s) caused by deficiencies of each of the B vitamins including folic acid
68. Define enteral nutrition
69. Describe the indications for total parenteral nutrition(TPN)
70. Explain the most common method for administering total parenteral nutrition
71. List three complications associated with total parenteral nutrition
72. Explain the emergent management when total parenteral nutrition is suddenly discontinued (for whatever reason)
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