NR-507 Mid-Term Study Guide
**50 questions, multiple choice
Hematology:
hematopoiesis erythropoietin
erythrocyte function and lifespan functions of hemoglobin
iron-deficiency anemia- (Microcytic)- small RBC *Iron de
...
NR-507 Mid-Term Study Guide
**50 questions, multiple choice
Hematology:
hematopoiesis erythropoietin
erythrocyte function and lifespan functions of hemoglobin
iron-deficiency anemia- (Microcytic)- small RBC *Iron deficiency common cause thalassemia- (Microcytic)
sickle-cell anemia- (Normocytic) hemolytic anemia- (Normocytic)
pernicious anemia- (Macrocytic)- large RBC *B12 or folate deficiency
Genitourinary/Renal:
anatomy and physiology of the kidney kidney filtration
nephron damage tubular reabsorption
conditions associated with renal failure calculi blockage of ureter
benign prostatic hypertrophy prerenal disease
intrarenal disease postrenal disease glomerulonephritis treatment of renal failure
role of angiotensin converting enzyme (ACE)
Pulmonary:
anticholinergic drugs treatment for asthma asthma
alveolar hyperinflation with asthma
chronic bronchitis and related acid/base disturbances perfusion
blood flow between the heart and lungs bronchioles
polycythemia vera
Cardiovascular:
heart valves S1 heart tone S2 heart tone
cardiac contractility
preload- ventricle stretch during DIASTOLE filling (Franks law)
afterload-(unload) ventricle excertion during SYSTOLE- pumping blood out of SL valves (Laplace law) diastole- End diastolic volume (EDV)- blood in ventricle before systole (120 mL)
systole- End systolic volume (ESV)- blood left in ventricle after systole (50mL) stroke volume- blood volume ejected by ventricle during systole (70mL) *↑HR=↓SV
cardiac output- volume of blood ejected by each ventricle per min, SV X HR (70mLx75bpm=5.25 L/min) heart failure- dysfunction=↓CO=↓perfusion
Congestive heart failure- LHF, *caused by HTN
Cor Pulmonale- RHF, * caused by pulmonary dysfunction
Hypertension- leads to HF
MIDTERM PATHO READINGS
WEEK 1: 1, 2, 7, 8, 9, 10, 11, 12, 13, 14 Cell/Caner/Immunity
WEEK 2: 3, 34, 35, 36 Acid-Base/F&E/Pulmonary
WEEK 3: 27, 28, 29, 30, 32, 33 Hematology/Cardiovascular
WEEK 4: 37, 38, 39 Renal
Hematology
Hematopoiesis (Hemato=blood Poiesis= to form or make) (blood = 7% BW)
● Process of creating new blood cells. All blood cells are made in the bone marrow. Stimulated by androgens (testosterone) & erythropoietin made by the kidney & liver in response to tissue hypoxia
● Stimulated by infiltration of yellow (fatty) bone marrow with red marrow cells
● All blood is created from hematopoietic stem cells (HSC)-(Hemocytoblast)
o Proliferate & differentiate by growth factors & cytokines to form RBC, WBC, & platelets
o 4 groups
▪ Lymphoid: T-cell (T-lymphocyte) & B-cell (B-lymphocyte)
▪ Myeloid: Monocyte & Granulocytes (WBC)
▪ Erythrocyte (RBC)
▪ Megakaryocyte (platelets),
● Site of formation:
o 3rd week gestation, yolk sac,
o 8th week gestation, liver & spleen
o 5th month gestation, bone marrow
o Birth-5yrs, red marrow
o 20+ years, larger bones (ilium, vertebrae, cranium, jaw, sternum, ribs, femur, humerus)
● Erythrocyte (RBC)
o Normal RBC level = 4.2-6.2 million mm = 45% of our blood volume
o Contains hemoglobin molecules: Oxygen carrying molecule, which regulate diffusion through a cell’s plasma membrane, to cells (Hgb can carry up to 4 molecules of oxygen)
▪ Carry oxygen to lungs & exchange it for carbon dioxide in the tissues
▪ Responsible for blood’s ruby-red color
▪ As many as 300 million Hgb molecules/RBC (90% dry weight RBC)
▪ Hbg= polypeptide chains (2alpha & 2 beta), 4 heme molecules, & 4 iron
o Oxyhemoglobin: Oxygen binds to iron in heme molecule, RED
o Deoxyhemoglobin: CO2 binds Hgb, released in lungs, BLUE
o Mature erythrocytes lack a nucleus & organelles, so it cannot synthesize protein or carry out oxidative reactions. Cannot divide = limited life span *Anaerobic metabolism only
o Biconcave, spherical disk, reversible
o Lifespan: 100-120 days, 1% circulating RBC replenished every 24 hours (2.5million RBC’s/second)
o Stages: (7-day process)
▪ Hemocytoblast (stem cell) binds with erythropoietin
▪ Proerythroblast- committed to morph into RBC
▪ Erythroblast- ribosome synthesis (2 phases)
▪ Normoblast- Hgb accumulation & nucleus ejection
▪ Reticulocyte – released into circulation, no nucleus, ribosome, or mitochondria
▪ RBC (once in bone marrow 1-2 days)
o Size: microcytic, normocytic, macrocytic
o Color: hypochromic, normorchromic, hyperchromic (due to Hgb level)
o Variability: Anisocytosis (size), poikilocytosis (shape)
..............................................................CONTINUED.......................................................
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