MEDC 527 Exam 2 | Questions and Answers What do electron-donating groups do to a benzene ring? EDGs activate the benzene ring since they increase the electron density, making it more nucleophilic What do electron-with
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MEDC 527 Exam 2 | Questions and Answers What do electron-donating groups do to a benzene ring? EDGs activate the benzene ring since they increase the electron density, making it more nucleophilic What do electron-withdrawing groups do to a benzene ring? EWGs deactivate the benzene ring since they decrease the electron density, making it less nucleophilic Which functional groups are considered neutral and do not ionize? Amides, alcohols, ketones, aldehydes, esters, and ethers What is pka for amines? 8-11 What is the pka for carboxylic acids? 3-5 What is the pka for phenols? 9-11 What is the pka for anilines? 3-5 What is the pka for imidazoles? 6.9 What is the pka for pyridines? 4-6 What is the pka for imides? 8-10 What is the pka for 1, 3-dicarbonyls? 11-13 What is the pka for imines? around 7 What is the relationship between hydrophobic groups and hydrophilic groups with solubility? Hydrophobic groups would decrease the solubility of the molecule; meanwhile, hydrophilic groups would increase the solubility of the molecule. What are the hydrophilic groups? -OH, -NH2, -COOH, -CONH2 What are the hydrophobic groups? Aromatic rings, long chains How can amines become more soluble? Aqueous mineral acids make the amines into an ionic salt group, making it soluble. Meanwhile, carboxylic acids, when combined with an amine group, create an amine-carboxylate salt, which is soluble. Which amino acids are non-polar with aliphatic r-groups? Glycine, Alanine, Proline, Valine, Leucine, Isoleucine, Methionine Chemical structure of glycine
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