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NAPLEX Comprehensive Practice Questions Newly Updated 2025 Content Outline From NABP

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NAPLEX Practice Questions 1. A 5-year-old female weighing 40 lbs requires acetaminophen for mild pain. The pharmacy has acetaminophen liquid 160 mg/5 mL. What is an appropriate dose? A. 3 mL q4 hours B. 6 mL q6 ...

NAPLEX Practice Questions 1. A 5-year-old female weighing 40 lbs requires acetaminophen for mild pain. The pharmacy has acetaminophen liquid 160 mg/5 mL. What is an appropriate dose? A. 3 mL q4 hours B. 6 mL q6 hours C. 9 mL q12 hours D. 11 mL q6 hours Answer: B Rationale: *Step 1: Convert lbs to kg: 40 lbs ÷ 2.2 = 18.18 kg.* *Step 2: Acetaminophen pediatric dosing is 10-15 mg/kg/dose q4-6h. Using 10 mg/kg: 10 mg × 18.18 kg = 181.8 mg/dose.* *Step 3: The concentration is 160 mg/5 mL = 32 mg/mL.* *Step 4: 181.8 mg ÷ 32 mg/mL = 5.68 mL (round to 6 mL). Option A (3 mL) provides only about 5 mg/kg, which is subtherapeutic. Option C (9 mL q12h) would be appropriate for 15 mg/kg dosing but incorrect frequency. Option D (11 mL) provides approximately 20 mg/kg, exceeding the recommended dose .* 2. MK is a 69-year-old male with osteoarthritis, hypertension, and dyslipidemia. Current medications: Advil 400 mg q6h PRN, Benicar HCT 40/25 mg daily, Lipitor 20 mg daily, Tylenol 650 mg q6h PRN. BP is 139/84 mmHg. The addition of which antihypertensive is most appropriate? A. Chlorthalidone B. Hydralazine C. Lopressor (metoprolol tartrate) D. Lotensin (benazepril) E. Procardia XL (nifedipine extended-release) Answer: E Rationale: *This patient's BP remains above goal (<130/80 mmHg) despite an ARB/thiazide combination. Adding a dihydropyridine calcium channel blocker (nifedipine XL) is appropriate as it represents a different preferred drug class. Option A (chlorthalidone) duplicates the current thiazide therapy. Option B (hydralazine) is not a preferred agent due to adverse effects. Option C (beta-blockers) are less effective for BP lowering without comorbidities. Option D (ACE inhibitor) should not be combined with an ARB due to increased risk of hyperkalemia and renal impairment .* 3. A 74-year-old male with dementia is being evaluated for new medications. Which agents could worsen his cognitive symptoms? (Select ALL that apply)

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