1. A drug is orally administered to a patient at a dose of 100 mg. It is known that the drug is 90%
bioavailable after oral administration. The total amount of drug available for oral absorption is:
a. 90 mg
b. 100 mg
...
1. A drug is orally administered to a patient at a dose of 100 mg. It is known that the drug is 90%
bioavailable after oral administration. The total amount of drug available for oral absorption is:
a. 90 mg
b. 100 mg
c. 50 mg
d. 10 mg
2. A drug is orally administered to a 70-kg adult at a dose of 100 mg. The drug follows a linear onecompartment model. The first-order absorption rate constant is 1.0 h-1 and the first-order
elimination rate constant is 0.1 h-1
. The drug has the volume of distribution of 10 L. The peak time
is:
a. 1.11 h
b. 2.56 h
c. 5.89 h
d. 6.93 h
3. For a single oral dosed drug that follows a linear one-compartment model with first-order
absorption and first-order elimination processes, increasing the dose the area under the
plasma drug level curve (AUC). Assume the bioavailability and total body clearance do not change.
a. Does not change
b. Increases
c. Decreases
d. None of the above
4. For a single orally administered drug that follows a linear one-compartment model with first-order
absorption and first-order elimination processes, increasing the dose will the time to reach the
maximal plasma drug concentration (peak time).
a. Shorten
b. Prolong
c. Not change
d. None of the above
5. A drug was formulated in two different dosage forms, oral solutions and oral tablets. These two
dosage forms were orally administered at the same single dose of 100 mg to two different groups of
healthy subjects, respectively. The drug was also intravenously given to healthy subjects at a single
dose of 20 mg. The blood samples were taken after dosing and assayed for plasma drug
concentrations. The plasma drug level curves were plotted and the areas under the curve (AUC)
were estimated. The average AUCs of the drug are 145.0 Pg h/mL from the oral solution, 116.0 Pg
h/mL from the oral tablet and 29.0 Pg h/mL from the IV injection, respectively. What is the absolute
bioavailability of the drug from the oral tablet? Assume the drug follows linear pharmacokinetics.
a. 100%
b. 125%
c. 400%
d. 80%
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