Examination Candidate Number: _____________
Desk Number: _____________
UNIVERSITY OF YORK
BSc Stage 1 Degree Examinations 2017-18
Department:
BIOLOGY
Title of Exam:
Genetics and Evolution
Time allowed: 1 hour and
...
Examination Candidate Number: _____________
Desk Number: _____________
UNIVERSITY OF YORK
BSc Stage 1 Degree Examinations 2017-18
Department:
BIOLOGY
Title of Exam:
Genetics and Evolution
Time allowed: 1 hour and 30 minutes
Total marks available for this paper: 50
● Answer all questions in the spaces provided on the examination paper
● The marks available for each question are indicated on the paper
● A calculator will be provided
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Answer all questions in the spaces provided
1. Explain how you would use a mutagenesis screen to identify cell division
cycle mutants in Schizosaccharomyces pombe. (5 marks)
You would screen for conditional or temperature sensitive mutants
because you would expect mutations in cell division cycle genes to be
lethal (1 mark). The yeast is mutagenised in permissive conditions, where
you would expect conditional mutants to have a wild-type phenotype (1
mark). The mutagenised yeast would be transferred to restrictive
conditions to reveal a cell division cycle mutant phenotype (1 mark). Cell
division cycle mutants do not progress through the cell cycle and arrest at
a specific point of the cell cycle (1 mark). This distinguishes them from
non-cell division cycle mutants, which would arrest immediately on transfer
to the restrictive conditions irrespective of their progression through the
cell cycle (1 mark).
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