Pharmacology > EXAM REVIEW > ATI Pharmacology - Proctored Evaluation 2021 (All)
Factors that Determine the intensity of drug responses a Prescribed Dose (Administration) 1 Dosage size, route, & timing of administration are important determinants of drug responses 2 Because of... poor patient adherence & medication errors, drugs are not administered as they are prescribed 3 Toxicity = drug is too high; Treatment failure = drug is too low b Administered Dose (Pharmokinetics) 1 Determines how much of administered dose gets to its site of action 2 Four major processes: absorption, distribution, metabolism, & excretion 3 Impact of body on drugs c Concentration at sites of action (Pharmodynamics) 1 Determines nature and intensity of response 2 Impact of drugs on the body 3 Drug-receptor interaction, patient’s functional state, & placebo effects d Sources of Variation: 1 Drug Interactions 2 Physiological Variables (age, gender, weight) 3 Pathological Variables (diminished functions of kidneys and liver, major organs of drug elimination) 4 Genetic Variable (can alter metabolism of drugs and predispose patient to unique interactions) Because all patients are unique, drug therapy must be tailored to each individual. VI The nursing considerations for Chapter 1 are: a Patients are unique and may respond to drugs differently from the expected effect. The nurse must be diligent in assessing patients’ responses to pharmacologic intervention. b Early identification of side effects allows for early intervention and helps prevent adverse responses. [Show More]
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