NOTE: These questions were taken from the old Pharmacology exams. Although obsolete questions
have been deleted, not all the points covered in these questions may have been emphasized this year.
1. How many days will i
...
NOTE: These questions were taken from the old Pharmacology exams. Although obsolete questions
have been deleted, not all the points covered in these questions may have been emphasized this year.
1. How many days will it take to attain steady state (>90%) blood levels of a drug with an elimination
rate constant of 2.8 day-1 if the drug is given at 10 µg every 2 hours?
A. 1 day
B. 4 days
C. 12 days
D. 24 days
E. Not enough information is given in this problem to reach an answer.
2. A major difference between ligand-gated ion channel receptors and ligand-activated G protein
coupled receptors is:
A. The former recognize endogenous neurotransmitters like acetylcholine and the latter
recognize synthetic drugs like propranolol.
B. The former are tyrosine kinase enzymes while the latter are transcription factors that signal
via endogenous lipophilic agonists like estrogen.
C. The former mediate fast synaptic transmission while the latter are slower and regulate
metabolic products of the cell.
D. The former are found only on neuronal cells while the latter are found only on non-neuronal
tissues.
E. None of the above.
3
Questions 3-4 refer to the dose-response curves below.
D
Response E
C
Log (DRUG)
3. In the graph above, the drug that is the most potent is:
A. A
B. B
C. C
D. D
E. E
4. In the graph above, which pair of curves might represent the effect of a non-competitive antagonist
(i.e. curves in the absence and presence of the antagonist)? Assume no receptor reserve exists.
A. A and B
B. D and A
C. A and C
D. B and E
E. None of the above
5. If the half-life of a drug is 12 hours, what can be said about this drug?
A. Following a single i.v. injection of the drug, almost all of it will be eliminated in one day.
B. 1/12 of the drug will be eliminated every hour.
C. The drug is eliminated by zero-order kinetics.
D. The drug should be administered every 12 hours.
E. None of the above is correct.
6. A drug has a volume of distribution of 35 liters and a half-life of 6 hours and has been given for
three weeks at a dose of 10 mg every 12 hours. If the drug is precipitously discontinued, what is the
minimum expected time for most (>90%) of the drug to be cleared from the plasma?
A. 6 hrs
B. 12 hrs
C. 24 hrs
D. 48 hrs
E. None of the above
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