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Queens UniversityBCHM 218PBA3
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BCHM 218 – Fall 2020 – Problem-Based Assignment #3 NOTE: PLEASE SUBMIT AS A SINGLE PDF DOCUMENT You are a scientist studying a rare cardiovascular disease caused by mutations in the gene INO80D ... . In order to understand the molecular mechanisms by which mutations in INO80D cause your disease of interest, you develop a strain of genetically modified “knockout” mice that bear a mutated copy of Ino80d, the functional equivalent to the INO80D gene in humans. 1. How would you define the relationship between INO80D and Ino80d (1 mark)? Please justify your answer (1 mark). 2. As illustrated in the schematic diagram below, the mutation in your knockout mice makes the Ino80d gene non-functional by deleting a 5,000 bp segment of the gene [Show More]
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