NR508_Midterm
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NR508 Midterm Outline
Chapter 1: The Role of the Advanced Practice Nurse as Prescriber
Roles and responsibilities of APRN prescribers: Collaborate w/ physician on best drug
to give patient, in dept
...
h knowledge of drugs, use pharma protocols, central role in
educating nurses & patients on appropriate use of drugs
Clinical judgement in Prescribing- Is a prescription the right tx? Goals of therapy,
effective drugs for the disease? Monitoring goals met? Cost?
Collaboration with other providers- different perspective on prescribing, critical for
quality patient care
Autonomy and Prescriptive authority- varies state to state. 21 states are independent
prescribing, 26 are autonomous.
Chapter 2: Review of Basic Principles of Pharmacology
Metabolism: Biotransformation/ Chemical change of drug structure
Enhance excretion, inactivate the drug, increase therapeutic action, activate pro-drug,
increase/decrease toxicity
Factors (Age, genetics, pregnancy, liver dz, time of day, environment, diet, alcohol, drug
interactions)
Drug Dose Determined:
a) Dose-response relationship
b) Therapeutic index: ratio of lethal dose/therapeutic dose
c) Plasma level profile: Onset of action time
d) Half-life
e) Bioavailability: % of drug absorbed & available. Effected by incomplete
absorption & first-pass metaboli
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