AQA GCSE COMBINED SCIENCE: TRILOGY 8464/B/1H Biology Paper 1H Question Paper + Mark scheme [MERGED] June 2022 *jun228464b1h01* IB/M/Jun22/E14 8464/B/1H For Examiner’s Use Question Mark 1 2

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AQA GCSE COMBINED SCIENCE: TRILOGY 8464/B/1H Biology Paper 1H Question Paper + Mark scheme [MERGED] June 2022 *jun228464b1h01* IB/M/Jun22/E14 8464/B/1H For Examiner’s Use Question Mark 1 ... 2 3 4 5 6 TOTAL Time allowed: 1 hour 15 minutes Materials For this paper you must have: • a ruler • a scientific calculator. Instructions • Use black ink or black ball-point pen. • Pencil should only be used for drawing. • Fill in the boxes at the top of this page. • Answer all questions in the spaces provided. • If you need extra space for your answer(s), use the lined pages at the end of this book. Write the question number against your answer(s). • Do all rough work in this book. Cross through any work you do not want to be marked. • In all calculations, show clearly how you work out your answer. Information • The maximum mark for this paper is 70. • The marks for questions are shown in brackets. • You are expected to use a calculator where appropriate. • You are reminded of the need for good English and clear presentation in your answers. Please write clearly in block capitals. Centre number Candidate number Surname Forename(s) Candidate signature I declare this is my own work. GCSE COMBINED SCIENCE: TRILOGY Higher Tier Biology Paper 1H H 2 *02* IB/M/Jun22/8464/B/1H There are no questions printed on this page DO NOT WRITE ON THIS PAGE ANSWER IN THE SPACES PROVIDED Do not write outside the box 3 *03* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the 0 1 Bacteria can cause a variety of diseases in humans. box 0 1 . 1 What are two similarities between a bacterial cell and an animal cell? [2 marks] Tick () two boxes. Both have a cell membrane. Both have a cell wall. Both have a nucleus. Both have cytoplasm. Both have plasmids. 0 1 . 2 Salmonella food poisoning is caused by bacteria in food. Give one symptom of salmonella food poisoning. Do not refer to vomiting or diarrhoea in your answer. [1 mark] Question 1 continues on the next page 4 *04* IB/M/Jun22/8464/B/1H Do not write outside the 0 1 box . 3 What is the name of the first antibiotic developed? [1 mark] A child with a severe bacterial infection was given a course of antibiotics. Figure 1 shows how the concentration of live bacteria in the child’s body changed when taking the course of antibiotics. Figure 1 5 *05* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 0 1 . 4 The concentration of live bacteria in the body continued to increase after starting the course of antibiotics. Suggest one reason why. [1 mark] 0 1 . 5 After 3 days of taking the antibiotic: • the child felt better • there were still bacteria in the child’s body. Why did the child feel better? [1 mark] Tick () one box. Bacteria had become immune to the antibiotic. The child had become resistant to the bacteria. There were fewer toxins in the body than at day 0 0 1 . 6 Suggest why doctors do not give antibiotics to patients with minor infections. [1 mark] Question 1 continues on the next page 6 *06* IB/M/Jun22/8464/B/1H Do not write outside the box 9 Figure 2 shows blood viewed using a microscope. Figure 2 0 1 . 7 A vaccine will stimulate the production of antibodies. Which part of the blood in Figure 2 produces antibodies? [1 mark] Tick () one box. A B C D 0 1 . 8 Which part of the blood in Figure 2 starts the clotting process? [1 mark] Tick () one box. A B C D 7 *07* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the 0 2 This question is about cell division. box 0 2 . 1 Write the biological structures from the box in the correct order of size. [1 mark] cell chromosome gene nucleus Smallest Largest Question 2 continues on the next page 8 *08* IB/M/Jun22/8464/B/1H Do not write outside the Figure 3 shows how a fertilised egg cell can produce specialised cells. box Figure 3 0 2 . 2 Name Process A. [1 mark] 0 2 . 3 How many cell divisions are needed to form a 16-cell embryo from the original fertilised egg cell? [1 mark] Number of cell divisions = 9 *09* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the 0 2 box . 4 In humans a fertilised egg cell contains 23 pairs of chromosomes. How many chromosomes will there be in each of the embryo cells? [1 mark] 0 2 . 5 Figure 4 represents a cell cycle for a human embryonic cell. Figure 4 Describe one change in the cell that occurs during each of the stages of the cell cycle. [3 marks] Stage 1 Stage 2 Stage 3 10 *10* IB/M/Jun22/8464/B/1H Do not write outside the Cell division is important in the growth of multicellular organisms. box 0 2 . 6 Figure 5 shows the mean height of boys and of girls from birth to age 18 years. Figure 5 11 *11* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 14 Compare the growth of boys with the growth of girls. Use data from Figure 5 in your answer. [6 marks] 0 2 . 7 Give one way that cell division by mitosis is important in fully grown animals. [1 mark] 12 *12* IB/M/Jun22/8464/B/1H Do not write outside the 0 3 Amylase is an enzyme that digests starch. box 0 3 . 1 Which organs in the human digestive system produce amylase? [1 mark] Tick () one box. Liver, small intestine and large intestine Salivary glands, stomach and liver Salivary glands, pancreas and small intestine Stomach, pancreas and large intestine A student investigated the effect of pH on the activity of amylase. This is the method used. 1. Prepare amylase solution at pH 5 2. Mix the amylase solution with starch in a boiling tube. 3. Remove a drop of the amylase-starch mixture every 30 seconds and test it for the presence of starch. 4. Record the time when all the starch has been digested. 5. Repeat steps 1 to 4 using amylase solution prepared at pH 6, then at pH 7 and then at pH 8 0 3 . 2 What was the independent variable in this investigation? [1 mark] 13 *13* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 0 3 . 3 Describe how the student would know when all the starch had been digested. [1 mark] 0 3 . 4 Figure 6 shows the student’s results. Figure 6 What was the optimum pH for the amylase? Use Figure 6. [1 mark] Optimum pH = 14 *14* IB/M/Jun22/8464/B/1H Do not write outside the A scientist did a different investigation. box This is the method used. 1. Prepare amylase solution at the optimum pH. 2. Mix the amylase solution with starch in a boiling tube. 3. Measure the concentration of sugar every 10 seconds for 2 minutes. Figure 7 shows the scientist’s results. Figure 7 0 3 . 5 How much time did it take for the amylase to digest all the starch? Use Figure 7. [1 mark] Time to digest all the starch = seconds 15 *15* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 15 0 3 . 6 Determine the rate of sugar production per minute at 40 seconds. [4 marks] Rate = arbitrary units per minute 0 3 . 7 Explain how the structure of enzyme molecules is related to the effect of pH on the activity of amylase. [6 marks] 16 *16* IB/M/Jun22/8464/B/1H Do not write outside the box 0 4 Photosynthesis is an important chemical reaction in plants. 0 4 . 1 Why is light needed for photosynthesis? [1 mark] 0 4 . 2 What is the equation for photosynthesis? [1 mark] Tick () one box. C6H12O6 + CO2 → 6O2 + 6 H2O CO2 + H2O → CH2O + O2 6 CO2 + 6 H2O → C6H12O6 + 6O2 6O2 + 6 H2O → C6H12O6 + 6 CO2 17 *17* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the 0 4 box . 3 A student investigated the effect of different colours of light on the rate of photosynthesis at room temperature. The student used pondweed in water. A piece of pondweed was placed in red light, then in blue light and then in green light. Each colour of light was the same intensity. Describe how the student should make accurate measurements to obtain valid results for the rate of photosynthesis. [4 marks] Question 4 continues on the next page 18 *18* IB/M/Jun22/8464/B/1H Do not write outside the A scientist investigated the effect of different wavelengths of light on the rate of box photosynthesis. The wavelength of light determines the colour of the light. Figure 8 shows the student’s results. Figure 9 shows the scientist’s results. Figure 8 19 *19* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 9 Figure 9 0 4 . 4 Why are the results for the two investigations presented differently? [2 marks] 0 4 . 5 Suggest the range in wavelength of green light. Use Figure 8 and Figure 9. [1 mark] Range in wavelength of green light = from nm to nm 20 *20* IB/M/Jun22/8464/B/1H Do not write outside the There are no questions printed on this page box DO NOT WRITE ON THIS PAGE ANSWER IN THE SPACES PROVIDED 21 *21* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 0 5 This question is about tumours. 0 5 . 1 Describe the similarities and differences between benign tumours and malignant tumours. [4 marks] Question 5 continues on the next page 22 *22* IB/M/Jun22/8464/B/1H Do not write outside the Figure 10 shows data about skin cancer in males and females for different age box groups in the UK. It shows: • the number of new cases of skin cancer in 1 year • the number of people with skin cancer per 100 000 population in 1 year. Figure 10 23 *23* Turn over ► IB/M/Jun22/8464/B/1H Do not write outside the box 0 5 . 2 There are no new cases of skin cancer diagnosed in people younger than 15 years of age. Explain why. [2 marks] 0 5 . 3 Give two conclusions about the number of new cases of skin cancer. Use Figure 10. [2 marks] 1 2 0 5 . 4 The data for the number of people with skin cancer is given per 100 000 population. Suggest why the data is not given as the total number of people. [1 mark] Question 5 continues on the next page 24 *24* IB/M/Jun22/8464/B/1H Do not write outside the Figure 10 box is repeated below. [Show More]

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