MOLECULAR REGULATION OF HEALTH AND DISEASE Reader HAP 3180

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1. MOLECULAR REGULATION OF ENERGY AND NUTRIENT METABOLISM............................................12 1.1. Introduction ...............MOLECULAR REGULATION OF HEALTH AND DISEASE...................... ..................................................................................12 1.2. Mitochondria....................................................................................................................16 1.3. Reprogramming of metabolism ..........................................................................................26 1.4. Regulation of Cellular Metabolic Activity...............................................................................33 1.5. Anti cancer strategies targeting metabolism.........................................................................42 1.6. References ......................................................................................................................49 2. MICROBIOTA IN HEALTH AND DISEASE ....................................................................................51 2.1. Gastrointestinal microbes ..................................................................................................51 2.2. Microbial components influencing host physiology.................................................................59 2.3. Concluding remarks and references ....................................................................................66 3. INTESTINAL HOMEOSTASIS IN HEALTH AND DISEASE................................................................70 3.1. Intestinal homeostasis – a delicate balancing act..................................................................70 3.2. Basic anatomy of the human gastrointestinal tract................................................................70 3.3. The epithelial barrier.........................................................................................................70 3.4. Secreted and membrane bound mucins keep microbes at a distance .......................................71 3.5. Antimicrobial peptides and proteins ....................................................................................72 3.6. Innate regulation of mammalian innate defenses ..................................................................72 3.7. Pattern recognition receptors and inflammatory signaling ......................................................73 3.8. Regulation of innate receptor recognition and signaling .........................................................75 3.9. Inflammatory bowel disease (IBD)......................................................................................77 3.10. References ....................................................................................................................80 4. TOXICOLOGY: EPIGENETICS ............................................................................................82 4.1 Epigenetics: an introduction..........................................................................................82 4.2 Epigenetics: mechanisms and molecular basis.................................................................85 4.3 Epigenetics in development ..........................................................................................91 4.4 Cancer epigenetics ......................................................................................................96 4.5 References ...............................................................................................................103 5. ENDOTHELIAL FUNCTION......................................................................................................104 5.1. Introduction ..................................................................................................................104 5.2. Endothelial dysfunction ...................................................................................................109 5.3. Atherosclerosis ..............................................................................................................112 5.4. References ....................................................................................................................117 [Show More]

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