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BioChemistry > EXAM > BioChem Midterm Question Bank (All)

BioChem Midterm Question Bank

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Unit 1 Week 1 Questions: Hemoglobin has the ability to display cooperative binding while myoglobin does not display this binding kinetic patter. Which of the following difference between the two proteins accounts for this difference in binding kinetics? Answer - B) the presence of quaternary structure in hemoglobin Unit 1, Week 1 Quiz: QUESTION 1 . An enzyme has a mutation within the substrate binding site that reduces the binding of the coenzyme needed for covalent catalysis. Which of the following is likely to result as a consequence of this mutation? ... The enzyme will not be able to form the transition state complex ... The enzyme will not be able to bind substrate ... The enzyme will function normally ... The enzyme will use an alternative coenzyme for the reaction . 1 points QUESTION 2 . A 19-year-old boy is diagnosed with Creutzfeldt-Jakob Disease which is caused by the introduction of an amyloid fold in the disease-causing protein. The introduction of this fold causes the protein to transition from a primarily α-helical structure to an aggregate of mostly β- sheets. This change in protein structure (leading to disease) is best attributed to changes in which of the following? Dr. Brogan - Primary structure - amino acid chain - secondary - adapt a conformation that is most thermodynamically favorable - tertiary - more complex domains. ... An amino acid change in the primary sequence . .. Folding of the secondary structures ... Change in hydrophobicity of the quaternary interfaces ... Association of tertiary domains ... A truncation of the protein product . 1 points QUESTION 3 . Prosthetic groups are complex nonprotein molecules that participate in catalysis by providing functional groups that form a covalent intermediate between the enzyme and the substrate. Which of the following is an example of a coenzyme or cofactor that participates in a covalent catalysis reaction? ... OH- ... Nicotinamide adenine dinucleotide (NADH) ... ATP ... Pyridoxal phosphate

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