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NURS6630-D1E. 2021

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Foundational Neuroscience Explain the agonist-to-antagonist spectrum of action of psychopharmacologic agents: To effectively diagnose and create a treatment plan for a patient the psychiatric menta... l health nurse practitioner must have knowledge of the agonist-to-antagonist spectrum and its effect on psychopharmacologic agents. When a patient is prescribed a psychopharmacologic agent the goals of the agent is to change a patient’s behavior by changing their perception, and way of thinking and feeling. The agent of choice will either increase activity at the synapse, or decrease activity at the synapse. When activity is increase at the synapse it is known as agonist. When activity is decrease at the synapse it is known as antagonist (Barron, 2018). The role of the agonist is to tie to a receptor site and create a response by stimulating an action. On the other hand an antagonist works against the chosen drug and obstructs the response of the drug (Prabhat, 2010). Compare and contrast the actions of g couple proteins and ion gated channels: Both are located in the membrane and signal transduction, however have different actions. G-protein use protein kinase to react to the binding of a molecule responsible for signaling by activating a G protein. The ion gated channels actions include gating the flow of ions between the cell membrane by allowing specific ions (like Ca2+, Cl-, Na+, or K+) to travel back and forth between the membrane (wikibooks, 2017). This action establishes a resting membrane potential, and forming action potentials. [Show More]

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