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Alison - Central Dogma and Genetic Medicine Student Worksheet.

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OVERVIEW This worksheet complements the Central Dogma and Genetic Medicine Click & Learn. PROCEDURE As you proceed through the Click & Learn, follow the instructions below and answer the questions in the spaces provided. 1. Let’s review! The central dogma of molecular biology refers to the process of gene expression. Write the definition of gene expression in your own words. 2. Click on the “Central Dogma” menu tab at the top of the screen. The table below outlines the steps in eukaryotic gene expression. Click on each tab or scroll through the page and briefly summarize each step below. Gene Expression Steps Molecules Involved What molecules and proteins are involved in this step? Summary What happens during this step? Transcription RNA Splicing mRNA Transport Translation Protein Processing Gene expression is the process by which gene information is used to synthesize a functional gene product that is able to produce protein as the end product. Completed polypeptide chain is folded into a 3D functional protein. This takes place in cytoplasm or ER and golgi system. RNA polymerase, DNA, RNA, intron, exon RNA polymerase transcribes a gene's DNA into RNA with complementary sequence. Spliceosome, RNA (introns and exon) RNA is edited. Spliceosome removes the introns and splices exons together to form mature mRNA. mRNA mRNA is moved from nucleus to cytoplasm of the cell. mRNA, tRNA, ribosomes, polypeptide Ribosome translate mRNA code into amino acids. Each amino acid is then brought to the ribosome by tRNA and added to a polypeptide chain. mRNA, tRNA, rRNA, amino acids This study source was downloaded by 100000847458768 from CourseHero.com on 09-07-2022 14:36:47 GMT -05:00 https://www.coursehero.com/file/80373074/Alison-Central-Dogma-and-Genetic-Medicine-Student-Worksheetpdf/ Central Dogma and Genetic Medicine Genetics Published January 2018 www.BioInteractive.org Page 2 of 4 Click & Learn Student Worksheet 3. Mutations in the DNA can affect the structure and function of proteins. Some mutations may even cause genetic diseases. Scientists and doctors can intervene at different points during gene expression to develop treatments for such genetic diseases—or genetic medicine. Let’s learn about the genetic medicines that are

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