Biochem C785 - WGU - Module 3 - All
Questions
Hb (hemoglobin) binds to CO (carbon monoxide) with a higher affinity than oxygen and stabilizes the
R (relaxed) state Correct Answer: True
When hemoglobin changes from
...
Biochem C785 - WGU - Module 3 - All
Questions
Hb (hemoglobin) binds to CO (carbon monoxide) with a higher affinity than oxygen and stabilizes the
R (relaxed) state Correct Answer: True
When hemoglobin changes from the T to the R, it has a high affinity for oxygen Correct Answer: True
When hemoglobin changes from the R to T, it has a low affinity for oxygen Correct Answer: True
Cooperatively refers to Correct Answer: structural changes that increases the affinity for oxygen in
hemoglobin
When the oxygen concentration is high, the heme shape is planar. When the oxygen concentration is
low, the heme shape is bent shape. Correct Answer: True
The Bohr effect is a relationship between hemoglobin's oxygen binding behavior in conjunction with
the pH of the surroundings. When the pH is low, hemoglobin has low affinity for oxygen and releases
oxygen Correct Answer: True
Bohr effect is a relationship between hemoglobin's oxygen binding behavior in conjunction with the
pH of the surroundings. When the pH is high, hemoglobin has high affinity for oxygen and binds
oxygen. Correct Answer: True
Relative to the lungs, the pH in the peripheral tissues is lower, because the CO2 generated by
metabolism is converted to bicarbonate, which releases proton (H+) Correct Answer: True
The Bohr effect is a relationship between hemoglobin's oxygen binding behavior in conjunction with
the pH of the surroundings. When the H+ ion concentration increases, the pH of the solution
decreases. Correct Answer: True
Myoglobin stores oxygen, whereas hemoglobin transports oxygen. Myoglobin has a higher affinity for
oxygen compared to hemoglobin Correct Answer: True
Hemoglobin is an oxygen transport protein, whereas myoglobin is an oxygen storage protein. They
exhibit different binding curves when plotted on a graph with total partial pressure of the oxygen (xaxis) plotted against the percentage saturation of hemoglobin (y-axis). What pattern of binding curves
do these proteins exhibit? Correct Answer: Hemoglobin has a sigmoidal curve whereas the
myoglobin has a hyperbolic curve.
Hemoglobin and myoglobin proteins bind to molecular oxygen. However, the protein part of the
hemoglobin does not bind directly to the oxygen. Instead a specific atom helps bind the oxygen -
Correct Answer: Iron
The symptoms of sickle cell anemia are primarily because red blood cells are misshaped, due to
Correct Answer: a mutation in the beta hemoglobin gene which leads to the insertion of valine into the
hydrophobic patches on deoxygenated hemoglobin
Relative to the peripheral tissues, the pH in lungs is higher, because Correct Answer: the protons
(H+) that were combined with hemoglobin quickly bind to bicarbonate (HCO3-) to form CO2; the CO2
is then exhaled
Why is carbon monoxide poisonous? Correct Answer: it binds hemoglobin 200 times better than
oxygen
BPG stabilizes the T (tense) states of hemoglobin Correct Answer: True
Even though the amino acids sequence between subunits of hemoglobin and myoglobin are not
exactly the same, there are other similarities between the two proteins. Which level of protein
structure is not found in both molecules? Correct Answer: Quarternary
In the deoxygenated state the heme is bent, where as in the oxygenated state, the heme is planar.
Correct Answer: True
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