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NR 507 Anemia pathophysiology

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NR 507 Anemia pathophysiology Anemia - ans --_______ is a hematological disorder characterized by a reduction in the total number of circulating red blood cells (RBCs) and/or a decrease in hemoglob ... in (Hb) amount or function. Anemia can be caused by? - ans --1) impaired RBC production, 2) excessive blood loss, 3) increased RBC destruction OR any combination of the three. Red Blood Cell (RBC) - ans --The number of erythrocytes in 1 cubic mm of whole blood. Normal for men is 4.7-6.1 mcL. Normal in women is 4.5-5.2 mcL. Hemoglobin (Hgb) - ans --The oxygen carrying pigment of red cells. Normal for men is 13.5-17.5 g/dL. Normal for women is 12.0-15.5 g/dL. Hematocrit (Hct) - ans --The volume of cells as a percentage of the total volume of cells and plasma in whole blood. Normal for women is 37-48%. Reticulocyte - ans --Immature RBCs. Used to assess bone marrow function. Normal in adults is approximately 3%. Mean Cell Volume (MCV) - ans --This measures the average size of the RBC. Normal is 80-100 fL. Mean Corpuscular Hemoglobin (MCH) - ans --Average weight of hemoglobin per red cell. Normal is 27-33 pg Mean Corpuscular Hemoglonin Concentration (MCHC) - ans --Average concentration of hemoglobin per erythrocyte. Normal is 32-36%. Red Cell Distribution Width - ans --The index of a quantitative estimate of the uniformity of individual cell size. Normal is 11.5-14.5% Anemia Classification - ans --Anemias can be classified into 3 categories based on the average size of the RBCs (MCV): Microcytic anemia (MCV<80 fL) describes RBCs that are small. Macrocytic anemia (MCV>100 fL) describes RBCs that are large. Normocytic anemia (MCV 80-99 fL) describes RBCs that are normal in size. Microcytic (MCV<80 fL) - ans --Iron deficiency Sideroblastic Thalassemia Anemia of chronic disease Normocytic (MCV 80-99 fL) - ans --Anemia of inflammation and chronic disease Hereditary spherocytosis** G6PD deficiency Paroxysmal nocturnal hemoglobinuria [Show More]

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