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ONS Chemotherapy Immunotherapy Certificate Exam 2022 with complete solution

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ONS Chemotherapy Immunotherapy Certificate Questions and Answers 1 / 13 1. 3 major phases of cell division:: Interphase Mitotic phase Cytokinesis 2. 3 steps of interphase:: First growth phase (G1) Synthesis phase ...

ONS Chemotherapy Immunotherapy Certificate Questions and Answers 1 / 13 1. 3 major phases of cell division:: Interphase Mitotic phase Cytokinesis 2. 3 steps of interphase:: First growth phase (G1) Synthesis phase (S phase) Second growth phase (G2) 3. 4 phases of mitosis:: Prophase Metaphase Anaphase Telophase 4. Innate immunity:: Non-specific response, either: 1. Barrier (skin, mucous membranes, flora of skin/gut) 2. Cellular components (phagocytes, natural killer cells, granulocytes, macrophages) 5. Adaptive immunity:: Follows innate immunity if unsuccessful. Memory immunity, including: 1. Humoral immunity (production of antibodies or immunoglobulins) 2. Cell mediated immunity (dependent upon T cells) 3. Regulatory T -cells (prevent autoimmune reactions and limit inflammatory responses) 6. Define mutations: Variations in the nucleotide sequence of a gene 7. 3 main goals of treatment:: Cure Control Palliation 8. Define neoadjuvant therapy: Treatment is given prior to surgery to shrink the tumor 9. Define adjuvant therapy: Additional cancer treatment given after the primary treatment to lower the risk that the cancer reoccur 10. Define conditioning/preparative therapy: Treatments used to prepare a patient for stem cell transplantation 11. 2 types of conditioning therapies:: Myeloablative Nonmyeloablative 12. Define dose density: Drug dose per unit of time 13. Define dose intensity: Amount of drug delivered over timeONS Chemotherapy Immunotherapy Certificate Questions and Answers 2 / 13 14. How is relative dose intensity (RDI) calculated?: By comparing the dose that the patient ACTUALLY received to the planned dose of the standard regimen 15. How do alkylating agents work?: By causing a break in the DNA helix strand, interfering with DNA replication and causing cell death 16. 3 subcategories of alkylating agents:: 1. Nitrogen mustards 2. Platinum-based agents (do not possess an alkyl group but still termed alkylating agents as they work similarly) 3. Nitrosoureas

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