NURSING > EXAM > Walden 6630 Psychopharmacology Midterm Study Guide (All)

Walden 6630 Psychopharmacology Midterm Study Guide

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1. Serotonin regulates: Mood, emotion, feeding, and reproductive behavior 2. This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to increase levels in the synaptic cleft ...

1. Serotonin regulates: Mood, emotion, feeding, and reproductive behavior 2. This class of antidepressants binds to presynaptic SERT and inhibits them from reuptake of serotonin to increase levels in the synaptic cleft to bind with postsysnaptic 5HT2 receptors: SSRIs 3. First line therapy for MDD due to milder side effect profiles: SSRIs 4. Six Common SSRIs: citalopram, escitalopram, fluoxetine, fluvoxamine, sertra- line, paroxetine 5. Onset of therapeutic benefit from SSRIs: 4-6 weeks 6. In addition to MDD, SSRIs also treat: Chronic Anxiety, PTSD, OCD, and eating disorders (bulimia) 7. Five Common side effects of SSRIs include: Anxiety, insomnia, GI distress, sexual dysfunction (ED), SIADH 8. Severe side effect of SSRIs in children/adolescents under age 25 years old: suicidal ideation 9. Life threatening adverse effect of SSRIs, especially when used in combi- nation with other serotonergic drugs (SNRIs, TCAs, MAOIs, etc.): Serotonin Syndrome 10. Excess accumulation of serotonin resulting in overstimulation of the nervous system: Serotonin Syndrome 11. Seven symptoms of Serotonin Syndrome: Flushing, hyperthermia, agita- tion, muscle rigidity, seizure, coma, HYPERreflexia 12. The treatment for serotonin syndrome: Cyproheptadine (5-HT2 receptor antagonist) 13. Cyproheptadine treats serotonin syndrome by: blocking 5-HT2 receptors (serotonin antagonist) 14. When SSRIs or SNRIs are stopped abruptly, common symptoms of with- drawal include: Irritability, headaches, and insomnia 15. Medicine specific side effect of citalopram: Prolonged QT interval (nor- mal=0.4.-0.44 seconds) 16. This SSRI is pregnancy category D due to associations with congenital heart defects: Paroxetine 17. All SSRIs but paroxetine (D) are pregnancy category: C 18. Three SSRIs that are inhibitors of Cytochrome P450 enzymes: fluoxetine, fluvoxamine, and paroxetine 19. Five common SNRIs include: duloxetine, venlafaxine, desvenlafaxine, mil- nacipran, levomilnacipran 20. This antidepressant class of medications works by binding to presynap- tic SERT a

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