How venodilator treatment reduces preload/end-diastolic volume Correct Answer: by decreasing venous return
How arterial dilator treatment reduces afterload/end-systolic volume Correct Answer: by decreasing arterial/
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How venodilator treatment reduces preload/end-diastolic volume Correct Answer: by decreasing venous return
How arterial dilator treatment reduces afterload/end-systolic volume Correct Answer: by decreasing arterial/aortic pressure
Description of O2 supply of heart Correct Answer: ATP synth by aerobic metab w/ interm O2 supply (not continuous bl supp b/c BVs supp myocard constr during systole)
- extr up to 70% O2 from blood
Pathophysiology of IHD Correct Answer: 1). Stable angina = chron disr bl supp to myocard tiss by asymp athero plaque
2). Stable ischemia/angina = stab fixed athero plaque
3). Unstable ischemia/angina = plaque disr+plt aggreg but not yet thrombus formation
4). NSTEMI = thrombus form but not compl occlusive
5). STEMI = compl occl thromb
Angina Pectoris Description & Types Correct Answer: press-like discomf/pain from myocard isch/underl athero --> O2 dem>O2 supp
- IHD = angina+MI
- Typ ang = O2 dem incr (ie. exerc/stress) but cor bl fl+O2 supp lim by athero
- Stab ang = sim angina attacks each time
- Unstab ang = ang attacks worse each time by rup plaque; MI forerunner
- Variant/Prinzmetal's ang = ac cor vasosp w/ pain @ rest --> TREAT w/ CCBs/BBs
Drug Classes used for Stable Angina Treatment Correct Answer: - Nitrites & Nitrates
- CCBs
- BBs
- Drugs modifying myocard metab
General Pharmacology of Drugs for Stable Angina Treatment Correct Answer: - Incr O2 supp by: incr reg fl distrib by nitrates, CCBs, BBs & incr cor bl fl by nitrates, CCBs
- Decr O2 dem by: decr HR+contractility by BBs, CCBs & decr wall tens (pre+afterload) by nitrates, CCBs
Examples & Use of Nitrites in Stable Angina Treatment Correct Answer: Amyl nitrite for ac ang by inhal
Examples & Use of Nitrates in Stable Angina Treatment Correct Answer: incl nitroglycerin, isosorbide dinitrate, isosorbide mononitrate
- Use = prev+treat ang attacks by pref relax ven sm musc (venodil)
- IV nitro also for MI-assoc ac HF
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