Sedative-hypnotic drug Correct Answer: causes sedation & anxiolysis or encourages sleep; all drugs in this class cause dose-dep CNS depr EXC for buspirone (non-sedating anxiolytic), propranolol (perf anxiety)
Diagnos
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Sedative-hypnotic drug Correct Answer: causes sedation & anxiolysis or encourages sleep; all drugs in this class cause dose-dep CNS depr EXC for buspirone (non-sedating anxiolytic), propranolol (perf anxiety)
Diagnoses treated with sedative-hypnotics Correct Answer: - Insomnia = diff falling asleep (sleep onset), staying asleep (sleep maint), waking up too early/not able go back to sleep
- Anxiety = ac anx, chron anx (persis worrying out of prop, overthinking/expecting worst case, aff daily func)
Addiction Correct Answer: PSYCH state resp to drug by which user compelled to use drug, suffers anx when sep from it
- chron, neurobio dis w/ drug use char by 1+ of these: compulsive, chronic, cont desp harm, impaired control, cravings
- high relapse risk even after successful w/drawal
Anesthesia Correct Answer: LOC assoc w/ absence resp to pain
Anxiolytic Correct Answer: drug red anxiety
Dependence Correct Answer: PHYS state resp to drug by which remov drug evokes unpleas/life-threat sx (often opp of drug effects)
- adap due to drug-spec w/drawal synd that prod by abrupt cessation, rap dose red, antag admin
Hypnosis Correct Answer: induction of sleep
REM sleep Correct Answer: sleep phase assoc w/ rap eye moves, incl most dreaming
Sedation Correct Answer: anxiety red prod calm/sleep
Tolerance Correct Answer: drug effect reduction req incr dosage to maint same resp
GABAa Receptors Correct Answer: func as Cl- chann w/ spec binding sites for benzos, barbs, Z-comps (Non-BZD BZD rec agonists)
MT1 & MT2 Receptors Correct Answer: GPCRs in suprachiasmatic nucl binding melatonin (endog ligand) or MRAs (melat rec agonists) promoting sleep onset
OX1 & OX2 (Hypocretin 1 & 2) Receptors Correct Answer: GPCRs (Gq & Gi/o) binding Orexin A & B (endog ligands), suvorexant, lemborexant --> GABA + glutamate rel
H1 Receptors Correct Answer: GPCRs (Gq) loc in CNS, sm musc, endoth & binding histamine (endog ligand) --> incr IP3 & DAG
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