Seizure Correct Answer: transitory alts in behav, sens, consciousness by abnl, synch, el d/c in br; most last 10 yrs w/o seizure + >5 yrs w/o AED ther
Symptomatic seizures Correct Answer: result of br dam, tum, les,
...
Seizure Correct Answer: transitory alts in behav, sens, consciousness by abnl, synch, el d/c in br; most last <5 mins
Epilepsy Correct Answer: - 2 unprov seizures 24+ hrs apart
- unprov seizures w/ prob further seizures @ least 60% over next 10 yrs
- dx epilepsy synd
AED discontinuation Correct Answer: considered if seizure free 2 yrs w/ risks vs. benefits
- one drug @ time, slow taper
Resolution of epilepsy Correct Answer: >10 yrs w/o seizure + >5 yrs w/o AED ther
Symptomatic seizures Correct Answer: result of br dam, tum, les, TBI, inf, etc
Idiopathic seizures Correct Answer: result of unk facs, pot genetic
Genes potentially affected in seizures Correct Answer: - v-g ion channs & syn rec esp GABAa rec
- comps NT rel machinery incl STXBP1 (syntaxin binding prot)
- neural adh mols like PCDH19
- syn dev prots like LGI1 (leucine-rich glioma inactiv-1)
Pathophysiology of seizures Correct Answer: - imbal inhib & excit NTs (ie. decr GABA & incr glut, Na+, Ca2+ chann activ)
- extracell ionic homeostasis disr
- abnl, rep & synch neur firing in cer cortex (abnl epileptiform d/c)
Etiology of seizures Correct Answer: - mech, metab (ie. hypogly), gen, fever, inf
- recr drugs (ie. cocaine, EtOH, stims, AEDs)
Risk factors for seizures Correct Answer: - br tumor
- abnl vasc dev
- bleeding in br
- infants small for gest age
- head inj/concussion + unconsciousness/mem loss
- skull fx
- encephalitis
- Alzheimer's dis
- ment retard
- stroke
- MS
- genetics
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