1. The primary inhibitory neurotransmitter in the brain is
A. Dopamine – excitatory, inhibitory
B. GABA*
C. Glutamate - excitatory
D. Serotonin - excitatory
Psychopharmacotherapy Keltner and Grant, Perese, page 2
2
...
1. The primary inhibitory neurotransmitter in the brain is
A. Dopamine – excitatory, inhibitory
B. GABA*
C. Glutamate - excitatory
D. Serotonin - excitatory
Psychopharmacotherapy Keltner and Grant, Perese, page 2
2. What differentiates atypical antipsychotic medications from first-generation or
typical antipsychotic medications?
A. 5HT2A receptor antagonist properties*
B. Specific dopamine receptor 3 and 5HT2A blockade
C. 5HT2A receptor agonist properties
D. Dopamine receptor 2 antagonist properties
Stahl’s essential psychopharmacology 4th edition, Chapter 5, page 141
3. Norepinephrine is produced in which of the following locations?
A. Hypothalamus
B. Locus ceruleus*
C. Ralphi nucleus
Psychopharmacotherapy, Keltner and Grant, page 164
4. You are treating a patient with schizophrenia who takes clozapine. What laboratory
values will indicate the patient needs to discontinue treatment?
A. White blood cell count of less than 1,800/mm3 and absolute neutrophil count of less than
1,200/mm3
B. Absolute neutrophil count of less than 2,000/mm3.
C. White blood cell count of less than 1,200/mm3
D. Absolute neutrophil count of less than 1,000/mm3*
Stahl’s prescriber’s guide, page 156, Dosing Tips: Treatment should be suspended if
WBC falls below 2,000 or is Absolute neutrophil count falls below 1,000
5. A shortage of this neurotransmitter can cause a lack of controlled movements such
as those experienced in Parkinson's disease. Conversely, an excess can cause
psychotic episodes seen in schizophrenia and severe mood disorders. This
neurotransmitter is
A. Dopamine* Too much dopamine causes positive symptoms of schizophrenia.
Antipsychotics block dopamine receptors. Dopamine depletions lead to Parkinson’s
disease symptoms
B. Norepinephrine
C. Serotonin
D. GABA
Psychopharmacotherapy, Perese, page 167; Overview of psychopharmacology Steele,
Grant, and Keltner page 65
6. A neurotransmission without a synapse is called
A. Classic neurotransmission
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B. Retrograde neurotransmission
C. Signal neurotransmission
D. Volume neurotransmission*
Stahl’s essential psychopharmacology 4th edition – page 6
7. Cytochrome P-450 enzymes are found in the
A. Brain
B. Liver
C. Bowel wall
D. Both b and c* Liver and bowel wall
Stahl’s essential psychopharmacology 4th edition – page 47
8. GABA transmission in the prefrontal cortex is increased by
A. Acetylcholine
B. Norepinephrine
C. Dopamine
D. Serotonin* Serotonin modulates neuronal activity in the prefrontal cortex and the
excitability of GABAegic interneurons in the cortex
Stahl’s essential psychopharmacology 4th edition – page 323
9. The limbic system is a more primitive part of the brain involved with
A. Aggressive behaviors
B. Cognitive deficits
C. Emotions*
D. Learning
Know the location of the limbic system (under the cerebellum) and is made up of
amygdala (emotions), hypothalamus, hippocampus. Limbic system is involved in
motivation, emotion, learning, memory. Prefrontal cortex and amygdala are linked to
emotional functioning, such as mood
Stahl’s essential psychopharmacology 4th edition – page 122
10. What mood stabilizer is best to help prevent suicide in patients with mood disorder?
A. Carbamazepine
B. Lamotrigine
C. Lithium*
D. Valproic acid
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